2021

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection.

Nat Immunol

Deeksha Munnur, Qiwen Teo, Denzel Eggermont, Horace HY Lee, Fabien Thery, Julian Ho, Sophie Wilhelmina van Leur, Wilson WS Ng, Lewis YL Siu, Antje Beling, Hidde Ploegh, Adan Pinto-Fernandez, Andreas Damianou, Benedikt Kessler, Francis Impens, Chris Ka Pun Mok and Sumana Sanyal

10.21203/rs.3.rs-63942/v1

Mit der Beteiligung von: TP02


Ring Finger Protein 213 Assembles into a Sensor for ISGylated Proteins with Antimicrobial Activity

Nat Commun

Fabien Thery, Lia Martina, Caroline Asselman, Heidi Repo, Yifeng Zhang, Koen Sedeyn, George D. Moschonas, Clara Bredow, Qi Wen Teo, Jingshu Zhang, Madeleine Vessely, Kevin Leandro, Denzel Eggermont, Delphine De Sutter, Katie Boucher, Tino Hochepied, Nele Festjens, Nico Callewaert, View ORCID ProfileXavier Saelens, View ORCID ProfileBart Dermaut, Klaus-Peter Knobeloch, Antje Beling, Sumana Sanyal, Lilliana Radoshevich, Sven Eyckerman, Francis Impens

10.1101/2021.06.03.446796

Mit der Beteiligung von: TP02


Immunohistochemical markers for histopathological diagnosis and differentiation of acute cutaneous graft-versus-host disease.

Exp Dermatol

Wegner J, Weidenthaler-Barth B, Engelbert J, Knothe M, Braun C, Helbig D, Sacher C, Kreft A, Wagner EM, Ziemer M, Meyer RG, von Stebut E.

10.1111/exd.14416

Mit Beteiligung von: TP15


CD27 expression on Treg cells limits immune responses against tumors.

J Mol Med (Berl).

Muth S, Klaric A, Radsak M, Schild H, Probst HC

10.1007/s00109-021-02116-9

Mit Beteiligung von: TP13


Unleashing the power of NK cells in anticancer immunotherapy.

J Mol Med (Berl).

Vogler M, Shanmugalingam S, Särchen V, Reindl LM, Grèze V, Buchinger L, Kühn M, Ullrich E.

10.1007/s00109-021-02120-z

TP12


Immunodominant Cytomegalovirus Epitopes Suppress Subdominant Epitopes in the Generation of High-Avidity CD8 T Cells.

Pathogens.

Freitag K, Hamdan S, Reddehase MJ, Holtappels R.

10.3390/pathogens10080956.

TP11, TP14


Direct Evidence for Viral Antigen Presentation during Latent Cytomegalovirus Infection.

Pathogens

Lemmermann NAW, Reddehase MJ

10.3390/pathogens10060731

TP11


Consequence of Histoincompatibility beyond GvH-Reaction in Cytomegalovirus Disease Associated with Allogeneic Hematopoietic Cell Transplantation: Change of Paradigm.

Viruses.

Reddehase MJ, Holtappels R, Lemmermann NAW.

10.3390/v13081530

TP11, TP14


Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation.

Proc Natl Acad Sci U S A.

Larochelle C, Wasser B, Jamann H, Löffel JT, Cui QL, Tastet O, Schillner M, Luchtman D, Birkenstock J, Stroh A, Antel J, Bittner S, Zipp F.

10.1073/pnas.2025813118

TP09


The neuroinflammation collection: a vision for expanding neuro-immune crosstalk in Brain.

Brain.

Irani SR, Nath A, Zipp F.

10.1093/brain/awab187

TP09


TNF-α blockade may lead to improvement of vascular function in psoriasis patients.

Exp Dermatol.

Wegner J, Karbach S, Drosos I, Schnorbus B, Muxel S, Schmidt F, Wenzel P, Waisman A, Münzel T, Gori T, von Stebut E.

10.1111/exd.14452

TP15


 Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity.

J Immunother Cancer.

Legscha KJ, Antunes Ferreira E, Chamoun A, Lang A, Awwad MHS, Ton GNHQ, Galetzka D, Guezguez B, Hundemer M, Bourdon JC, Munder M, Theobald M, Echchannaoui H.

10.1136/jitc-2020-001846

TP06


Targeting Immune Modulators in Glioma While Avoiding Autoimmune Conditions.

Cancers (Basel).

Bitar L, Schumann U, König R, Zipp F, Schmidt MHH.

10.3390/cancers13143524

TP04, TP09


Pathogenic lipid-binding antiphospholipid antibodies are associated with severity of COVID-19.

J Thromb Haemost.

Hollerbach A, Müller-Calleja N, Pedrosa D, Canisius A, Sprinzl MF, Falter T, Rossmann H, Bodenstein M, Werner C, Sagoschen I, Münzel T, Schreiner O, Sivanathan V, Reuter M, Niermann J, Galle PR, Teyton L, Ruf W, Lackner KJ.

10.1111/jth.15455

TP02, TP08, TP10


Advocacy of targeting protease-activated receptors in severe coronavirus disease 2019.

Br J Pharmacol.

Subramaniam S, Ruf W, Bosmann M

10.1111/bph.15587

TP02TP10


Exploration of Analgesia with Tramadol in the Coxsackievirus B3 Myocarditis Mouse Model

Viruses

Pinkert S, Kespohl M, Kelm N, Kaya Z, Heuser A, Klingel K, Beling A

10.3390/v13071222

TP02


Coxsackievirus B3 Exploits the Ubiquitin-Proteasome System to Facilitate Viral Replication.

Viruses

Voss M, Braun V, Bredow C, Kloetzel PM, Beling A.

10.3390/v13071360

TP02


Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.

Nat Commun.

Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, Klein M, Wempe A, Leister H, Raifer H, Picard F, Muhammad K, Ohl K, Romero R, Fischer F, Bauer CA, Huber M, Gress TM, Lauth M, Danhof S, Bopp T, Nerreter T, Mulder IE, Steinhoff U, Hudecek M, Visekruna A.

10.1038/s41467-021-24331-1. PMID: 34210970; PMCID: PMC8249424.

TP01


Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.

JCI Insight

Czauderna C, Poplawski A, O Rourke CJ, Castven D, Pérez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder DA, Schindeldecker M, Straub BK, Galle PR, Andersen JB, Thorgeirsson SS, Park YN, Marquardt JU.

10.1172/jci.insight.146196.

TP07


Depletion of CD56+CD3+ invariant natural killer T cells prevents allergen-induced inflammation in humanized mice

J Allergy Clin Immunol

Ose R, Weigmann B, Schuppan D, Waisman A, Saloga J, Bellinghausen I

10.1016/j.jaci.2021.05.005

TP15


Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany

Gene Ther

Albinger N, Hartmann J, Ullrich E

10.1038/s41434-021-00246-w

TP12


The neuroinflammation collection: a vision for expanding neuro-immune crosstalk in Brain

Brain

Irani SR, Nath A, Zipp F

10.1093/brain/awab187

TP09


Characterization and Manipulation of the Crosstalk Between Dendritic and Natural Killer Cells Within the Tumor Microenvironment

Front Immunol

Jacobs B, Gebel V, Heger L, Grèze V, Schild H, Dudziak D, Ullrich E

10.3389/fimmu.2021.670540

TP12, TP13


OpenTIMS, TimsPy, and TimsR: Open and Easy Access to timsTOF Raw Data

J Proteome Res

Łącki MK, Startek MP, Brehmer S, Distler U, Tenzer S

10.1021/acs.jproteome.0c00962

TPZ01


Stochastic Episodes of Latent Cytomegalovirus Transcription Drive CD8 T-Cell "Memory Inflation" and Avoid Immune Evasion

Front Immunol

Griessl M, Renzaho A, Freitag K, Seckert CK, Reddehase MJ, Lemmermann NAW

10.3389/fimmu.2021.668885

TP11


The Consumption of Cholesterol-Enriched Diets Conditions the Development of a Subtype of HCC with High Aggressiveness and Poor Prognosis

Cancers (Basel)

Simoni-Nieves A, Salas-Silva S, Chávez-Rodríguez L, Escobedo-Calvario A, Desoteux M, Bucio L, Souza V, Miranda-Labra RU, Muñoz-Espinosa LE, Coulouarn C, Gutiérrez-Ruiz MC, Marquardt JU, Gomez-Quiroz LE

10.3390/cancers13071721

TP07


Revisiting Current Concepts on the Tolerogenicity of Steady-State Dendritic Cell Subsets and Their Maturation Stages

Lutz MB, Backer RA, Clausen BE

DOI: 10.4049/jimmunol.2001315

TP14


Arming Immune Cells for Battle: A Brief Journey through the Advancements of T and NK Cell Immunotherapy

Philipp Wendel, Lisa Marie Reindl, Tobias Bexte, Leander Künnemeyer, Vinzenz Särchen, Nawid Albinger, Andreas Meckensen, Eva Rettinger, Tobias Bopp, Evelyn Ullrich

Cancers

DOI: 10.3390/cancers13061481

TP01, TP12


Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany

Nawid Albinger, Jessica Hartmann, Evelyn Ullrich

Gene Therapy

DOI: 10.1038/s41434-021-00246-w

TP12


Motor ability, physical self-concept and health-related quality of life in pediatric cancer survivors

Cancer Med

Benzing V, Siegwart V, Spitzhüttl J, Schmid J, Grotzer M, Roebers CM, Steinlin M, Leibundgut K, Everts R, Schmidt M

10.1002/cam4.3750

TP09


New 3-Aryl-2-(2-thienyl)acrylonitriles with High Activity Against Hepatoma Cells

Int J Mol Sci

Schaller E, Ma A, Gosch LC, Klefenz A, Schaller D, Goehringer N, Kaps L, Schuppan D, Volkamer A, Schobert R, Biersack B, Nitzsche B, Höpfner M

10.3390/ijms22052243

TP08


Selective elimination of immunosuppressive T cells in patients with multiple myeloma

Leukemia

Awwad MHS, Mahmoud A, Bruns H, Echchannaoui H, Kriegsmann K, Lutz R, Raab MS, Bertsch U, Munder M, Jauch A, Weisel K, Maier B, Weinhold N, Salwender HJ, Eckstein V, Hänel M, Fenk R, Dürig J, Brors B, Benner A, Müller-Tidow C, Goldschmidt H, Hundemer M

DOI: 10.1038/s41375-021-01172-x

TP06


Druggable genome and precision medicine in cancer: current challenges

FEBS J

Dupont CA, Riegel K, Pompaiah M, Juhl H, Rajalingam K

DOI: 10.1111/febs.15788

TP05


Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection

Basic Res Cardiol

Goetzke CC, Althof N, Neumaier HL, Heuser A, Kaya Z, Kespohl M, Klingel K, Beling A

DOI: 10.1007/s00395-021-00848-w

TP02


IL-17 controls central nervous system autoimmunity through the intestinal microbiome

Sci Immunol

Regen T, Isaac S, Amorim A, Núñez NG, Hauptmann J, Shanmugavadivu A, Klein M, Sankowski R, Mufazalov IA, Yogev N, Huppert J, Wanke F, Witting M, Grill A, Gálvez EJC, Nikolaev A, Blanfeld M, Prinz I, Schmitt-Kopplin P, Strowig T, Reinhardt C, Prinz M, Bopp T, Becher B, Ubeda C, Waisman A

DOI: 10.1126/sciimmunol.aaz6563

TP01, TP15


The inflammatory pathogenesis of colorectal cancer

Nat Rev Immunol

Schmitt M, Greten FR

10.1038/s41577-021-00534-x

TP16


Immune cell - produced ROS and their impact on tumor growth and metastasis

Redox Biol

Kennel KB, Greten FR

10.1016/j.redox.2021.101891

TP16