2022

Hyperglycemia and Not Hyperinsulinemia Mediates Diabetes-Induced Memory CD8 T-Cell Dysfunction

Diabetes

Kavazović I, Krapić M, Beumer-Chuwonpad A, Polić B, Turk Wensveen T, Lemmermann NA, van Gisbergen KPJM, Wensveen FM

10.2337/db21-0209

TP11


Memory CD8 T Cells Protect against Cytomegalovirus Disease by Formation of Nodular Inflammatory Foci Preventing Intra-Tissue Virus Spread

Viruses

Holtappels R, Podlech J, Freitag K, Lemmermann NA, Reddehase MJ

10.3390/v14061145

TP11


Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis

Cell Mol Gastroenterol Hepatol

Yang AT, Kim YO, Yan XZ, Abe H, Aslam M, Park KS, Zhao XY, Jia JD, Klein T, You H, Schuppan D

10.1016/j.jcmgh.2022.12.005

TP08


Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin

Int J Oncol

Stern L, Boehme LF, Goetz MR, Nitschke C, Giannou A, Zhang T, Güngör C, Reeh M, Izbicki JR, Fliegert R, Hausen A, Giese N, Hackert T, Niv MY, Heinrich S, Gaida MM, Ghadban T

10.3892/ijo.2022.5454

TP22, TPQ01


Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma

Matrix Biol

Yan B, Liu L, Zhao L, Hinz U, Luo Y, An X, Gladkich J, de la Torre C, Huang Z, Schrapel D, Gross W, Fortunato F, Schaefer M, Gaida MM, Herr I

10.1016/j.matbio.2022.11.002

TP22, TPQ01


Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues

Eur J Immunol

Probst HC, Stoitzner P, Amon L, Backer RA, Brand A, Chen J, Clausen BE, Dieckmann S, Dudziak D, Heger L, Hodapp K, Hornsteiner F, Hovav AH, Jacobi L, Ji X, Kamenjarin N, Lahl K, Lahmar I, Lakus J, Lehmann CHK, Ortner D, Picard M, Roberti MP, Rossnagel L, Saba Y, Schalla C, Schlitzer A, Schraml BU, Schütze K, Seichter A, Seré K, Seretis A, Sopper S, Strandt H, Sykora MM, Theobald H, Tripp CH, Zitvogel L

10.1002/eji.202249819

TP13, TP20


Guidelines for DC preparation and flow cytometry analysis of mouse lymphohematopoietic tissues

Eur J Immunol

Amon L, Dudziak D, Backer RA, Clausen BE, Gmeiner C, Heger L, Jacobi L, Lehmann CHK, Probst HC, Seichter A, Tchitashvili G, Tochoedo NR, Trapaidze L, Vurnek D

10.1002/eji.202249893

TP13, TP20


SimBu: bias-aware simulation of bulk RNA-seq data with variable cell-type composition

Bioinformatics

Dietrich A, Sturm G, Merotto L, Marini F, Finotello F, List M

10.1093/bioinformatics/btac499

TP19


Magnetique: an interactive web application to explore transcriptome signatures of heart failure

J Transl Med

Britto-Borges T, Ludt A, Boileau E, Gjerga E, Marini F, Dieterich C

10.1186/s12967-022-03694-z

TP19


Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells

Front Immunol

Braband KL, Kaufmann T, Floess S, Zou M, Huehn J, Delacher M

10.3389/fimmu.2022.1082055

TP19


Guidelines for mouse and human DC functional assays

Eur J Immunol

Clausen BE, Amon L, Backer RA, Berod L, Bopp T, Brand A, Burgdorf S, Chen L, Da M, Distler U, Dress RJ, Dudziak D, Dutertre CA, Eich C, Gabele A, Geiger M, Ginhoux F, Giusiano L, Godoy GJ, Hamouda AEI, Hatscher L, Heger L, Heidkamp GF, Hernandez LC, Jacobi L, Kaszubowski T, Kong WT, Lehmann CHK, López-López T, Mahnke K, Nitsche D, Renkawitz J, Reza RA, Sáez PJ, Schlautmann L, Schmitt MT, Seichter A, Sielaff M, Sparwasser T, Stoitzner P, Tchitashvili G, Tenzer S, Tochoedo NR, Vurnek D, Zink F, Hieronymus T

10.1002/eji.202249925

TP01, TP11, TP18, TP20, TPQ01 


Image-guided radiotherapy in an orthotopic mouse model of rectal cancer

STAR Protoc

Nicolas AM, Pesic M, Rödel F, Fokas E, Greten FR

10.1016/j.xpro.2022.101749

TP16


Cancer-associated fibroblasts in inflammation and anti-tumor immunity

Clin Cancer Res

Kennel KB, Bozlar M, De Valk AF, Greten FR

10.1158/1078-0432.CCR-22-1031

TP16


Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Immunity

Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux PA, Rinsch C, Greten FR

TP16


Inflammation: the incubator of the tumor microenvironment

Trends Cancer

Denk D, Greten FR

10.1016/j.trecan.2022.07.002

TP16


Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Nature

Schmitt M, Ceteci F, Gupta J, Pesic M, Böttger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisözü A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR

10.1038/s41586-022-05426-1

TP16


Hepatic interleukin-1 receptor type 1 signalling regulates insulin sensitivity in the early phases of nonalcoholic fatty liver disease

Clin Transl Med

Gehrke N, Hofmann LJ, Straub BK, Rühle F, Waisman A, Galle PR, Schattenberg JM

10.1002/ctm2.1048

TP15


NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition

Mol Metab

Vesting AJ, Jais A, Klemm P, Steuernagel L, Wienand P, Fog-Tonnesen M, Hvid H, Schumacher AL, Kukat C, Nolte H, Georgomanolis T, Altmüller J, Pasparakis M, Schmidt A, Krüger M, Supprian MS, Waisman A, Straub BK, Raschzok N, Bernier M, Birkenfeld AL, Hövelmeyer N, Brüning JC, Wunderlich FT

10.1016/j.molmet.2022.101626

TP15, TP20


Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mic

Cardiovasc Res

Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A

10.1093/cvr/cvab359

TP15


Antigen targeting to dendritic cells: Still a place in future immunotherapy?

Eur J Immunol

Stoitzner P, Romani N, Rademacher C, Probst HC, Mahnke K

10.1002/eji.202149515

TP13


Dithranol as novel co-adjuvant for non-invasive dermal vaccination

NPJ Vaccines

Sohl J, Hartmann AK, Hahlbrock J, Bartneck J, Stassen M, Klein M, Bros M, Grabbe S, Marini F, Woods K, Guezguez B, Mack M, Schild H, Muth S, Melchior F, Probst HC, Langguth P, Radsak MP

10.1038/s41541-022-00530-9

TP13, TP19, TP21


Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia

Leukemia

Koschade SE, Klann K, Shaid S, Vick B, Stratmann JA, Thölken M, Meyer LM, Nguyen TD, Campe J, Moser LM, Hock S, Baker F, Meyer CT, Wempe F, Serve H, Ullrich E, Jeremias I, Münch C, Brandts CH

10.1038/s41375-022-01678-y

TP12


Mitochondrial apoptosis: facilitator of NK cell-mediated immunotherapy

Signal Transduct Target Ther

Ullrich E, Vogler M, von Metzler I

10.1038/s41392-022-01126-4

TP12


Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects

Brain Behav Immun

Daguano Gastaldi V, Bh Wilke J, Weidinger CA, Walter C, Barnkothe N, Teegen B, Luessi F, Stöcker W, Lühder F, Begemann M, Zipp F, Nave KA, Ehrenreich H

10.1016/j.bbi.2022.10.016

TP09


Multiomic analysis of papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCδ for tumorigenesis

Mol Cancer

Renaud E, Riegel K, Romero R, Suryamohan K, Distler U, Tenzer S, Schad A, Musholt TJ, Rajalingam K

10.1186/s12943-022-01665-y

TP05, TP11, TPQ01


Cellular Immune Dysfunction in Obstructive Sleep Apnea

Front Surg

Ludwig K, Huppertz T, Radsak M, Gouveris H

10.3389/fsurg.2022.890377

TP21


Advocacy of targeting protease-activated receptors in severe coronavirus disease 2019

Br J Pharmacol

Subramaniam S, Ruf W, Bosmann M

10.1111/bph.15587

TP02


A cytosolic disulfide bridge-supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A

FEBS J

Voss M, Kleinau G, Gimber N, Janek K, Bredow C, Thery F, Impens F, Schmoranzer J, Scheerer P, Kloetzel PM, Beling A

10.1111/febs.16368

TP02


Use of Autoreactive Antibodies in Blood of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasms (IPMN) for Grade Distinction and Detection of Malignancy

Cancers(Basel)

Brindl N, Boekhoff H, Bauer AS, Gaida MM, Dang HT, Kaiser J, Hoheisel JD, Felix K

10.3390/cancers14153562

TP22TPQ01


Recent advances in targeting protein kinases and pseudokinases in cancer biology

Front Cell Dev Biol

Riegel K, P Vijayarangakannan, P Kechagioglou, K Bogucka, K Rajalingam

10.3389/fcell.2022.942500

TP05


CRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myeloma

OncoImmunology

Bexte T, Alzubi J, Reindl LM, Wendel P, Schubert R, Salzmann-Manrique E, von Metzler I, Cathomen T, Ullrich E

10.1080/2162402X.2022.2081415

TP12


Gamma Irradiation Triggers Immune Escape in Glioma-Propagating Cells

Cancers (Basel)

Hoppmann N, Heinig N, Distler U, Kim E, Lennerz V, Krauß Y, Schumann U, Giese A, Tenzer S, Bitar L, Schmidt MHH

10.3390/cancers14112728

TP09, TP11, TPQ01


Stress Granules determine the Development of Obesity-associated Pancreatic Cancer

Cancer Discov

Fonteneau G, Redding A, Hoag-Lee H, Sim ES, Heinrich S, Gaida MM, Grabocka E

10.1158/2159-8290.CD-21-1672

TP22


Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy

Clin Epigenetics

Neuberger EWI, Sontag S, Brahmer A, Philippi KFA, Radsak MP, Wagner W, Simon P

10.1186/s13148-022-01245-3

TP21


Stimulation of a subset of natural killer T cells by CD103 + DC is required for GM-CSF and protection from pneumococcal infection

Cell Rep

Murray MP, Crosby CM, Marcovecchio P, Hartmann N, Chandra S, Zhao M, Khurana A, Zahner SP, Clausen BE, Coleman FT, Mizgerd JP, Mikulski Z, Kronenberg M

10.1016/j.celrep.2021.110209

TP20


NF-κB in control of regulatory T cell development, identity, and function

J Mol Med (Berl)

Hövelmeyer N, Schmidt-Supprian M, Ohnmacht C

10.1007/s00109-022-02215-1

TP20


ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers

Sci Adv

Mooz J, Riegel K, Ps H, Sadanandam A, Marini F, Klein M, Werner U, Roth W, Wilken-Schmitz A, Tegeder I, Rajalingam K

10.1126/sciadv.abk1538

TP05, TP19


Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer

Cancer cell

Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR

10.1016/j.ccell.2022.01.004

TP16


Epicutaneous application of Imiquimod to model psoriasis-like skin disease induces water-saving aestivation motifs and vascular inflammation

J Invest Dermatol

Wild J, Ringen J, Bieler T, Knopp T, Lagrange J, Molitor M, Sies K, Kropp A, Keller K, Daiber A, Münzel T, Rauh M, Waisman A, Wenzel P, Titze J, Karbach S

10.1016/j.jid.2022.04.023

TP15


Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure

Cell Death Dis

Gehrke N, Wörns MA, Mann A, Hövelmeyer N, Waisman A, Straub BK, Galle PR, Schattenberg JM

10.1038/s41419-022-04946-y

TP15, TP20


CD4 + T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival

Cell Rep

Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T, Croxford AL, Nikolav A, Hövelmeyer N, von Stebut E, Prinz M, Ubeda C, Maloy KJ, Gagliani N, Flavell RA, Waisman A, Huber S

10.1016/j.celrep.2022.110565

TP15, TP20


Epitope length variants balance protective immune responses and viral escape in HIV-1 infection

Cell Rep

Pymm P, Tenzer S, Wee E, Weimershaus M, Burgevin A, Kollnberger S, Gerstoft J, Josephs TM, Ladell K, McLaren JE, Appay V, Price DA, Fugger L, Bell JI, Schild H, van Endert P, Harkiolaki M, Iversen AKN

10.1016/j.celrep.2022.110449

TP13, TPQ01


Antigen targeting to dendritic cells: Still a place in future immunotherapy?

Eur J Immunol

Stoitzner P, Romani N, Rademacher C, Probst HC, Mahnke K

10.1002/eji.202149515

TP13


Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy

Cell Death Discov

Särchen V, Shanmugalingam S, Kehr S, Reindl LM, Greze V, Wiedemann S, Boedicker C, Jacob M, Bankov K, Becker N, Wehner S, Theilen TM, Gretser S, Gradhand E, Kummerow C, Ullrich E, Vogler M

10.1038/s41420-021-00812-6

TP12


Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia

Blood Cancer J

Albinger N, Pfeifer R, Nitsche M, Mertlitz S, Campe J, Stein K, Kreyenberg H, Schubert R, Quadflieg M, Schneider D, Kühn MWM, Penack O, Zhang C, Möker N, Ullrich E

10.1038/s41408-022-00660-2

TP12


T Helper Cell Lineage-Defining Transcription Factors: Potent Targets for Specific GVHD Therapy?

Front Immunol

Campe J, Ullrich E

10.3389/fimmu.2021.806529

TP12


The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions

Cell Death Dis

Eichler M, Distler U, Nasrullah U, Krishnan A, Kaulich M, Husnjak K, Eberhardt W, Rajalingam K, Tenzer S, Pfeilschifter J, Imre G

10.1038/s41419-022-04829-2

TP05, TP11, TPQ01


Mast Cells Meet Cytomegalovirus: A New Example of Protective Mast Cell Involvement in an Infectious Disease

Cells

Becker S, Reddehase MJ, Lemmermann NA

10.3390/cells11091402

TP11


Host-Adapted Gene Families Involved in Murine Cytomegalovirus Immune Evasion

Viruses

Becker S, Fink A, Podlech J, Reddehase MJ, Lemmermann NA

10.3390/v14010128

TP11


Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation

Int J Mol Sci

Mandel J, Casari M, Stepanyan M, Martyanov A, Deppermann C

10.3390/ijms23073868

TP08


Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease

Hepatology

Karl M, Hasselwander S, Zhou Y, Reifenberg G, Kim YO, Park KS, Ridder DA, Wang X, Seidel E, Hövelmeyer N, Straub BK, Li H, Schuppan D, Xia N

10.1002/hep.32428

TP08, TP20


Fluorescence Correlation Spectroscopy Monitors the Fate of Degradable Nanocarriers in the Blood Stream

Biomacromolecules

Schmitt S, Huppertsberg A, Klefenz A, Kaps L, Mailänder V, Schuppan D, Butt HJ, Nuhn L, Koynov K

10.1021/acs.biomac.1c01407

TP08


Enhanced but variant-dependent serological and cellular immune responses to third-dose BNT162b2 vaccination in patients with multiple myeloma

Cancer Cell

Julius C Enssle, Julia Campe, Sarah Büchel , Alina Moter, Frederic See, Katharina Grießbaum, Michael A Rieger, Sebastian Wolf, Olivier Ballo, Björn Steffen, Hubert Serve, Holger F Rabenau, Marek Widera, Melanie Bremm, Sabine Huenecke, Sandra Ciesek, Ivana von Metzler, Evelyn Ullrich

10.1016/j.ccell.2022.05.003

TP05, TP12


Severe impairment of T-cell responses to BNT162b2 immunization in patients with multiple myeloma

Blood

Julius C Enßle, Julia Campe, Amelie Schwenger, Eliza Wiercinska, Helen Hellstern, Ralf Dürrwald, Michael A Rieger, Sebastian Wolf, Olivier Ballo, Björn Steffen, Hubert Serve, Halvard Bonig, Holger F Rabenau, Marek Widera, Sandra Ciesek, Ivana von Metzler, Evelyn Ullrich

10.1182/blood.2021013429

TP05, TP12


A cytosolic disulfide bridge-supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A

FEBS J

Martin Voss, Gunnar Kleinau, Niclas Gimber, Katharina Janek, Clara Bredow, Fabien Thery, Francis Impens, Jan Schmoranzer, Patrick Scheerer, Peter-Michael Kloetzel, Antje Beling

10.1111/febs.16368

TP02


A Conserved Cysteine Residue in Coxsackievirus B3 Protein 3A with Implication for Elevated Virulence

Viruses

Martin Voss, Sandra Pinkert, Meike Kespohl,Niclas Gimber, Karin Klingel, Jan Schmoranzer, Michael Laue, Matthias Gaida, Peter-Michael Kloetzel, Antje Beling

10.3390/v14040769

TP02