Linking the intestinal microbiome and immune mediated effects to primary tumor growth and therapy
We aim to examine how systemically elevated Reg3β levels can block tumorigenesis. Considering that tumor suppression is correlated with an increased CD8+ T cell infiltration into tumors as well as changes in the intestinal microbiome we intend to evaluate whether Reg3b-induced dysbiosis promotes a tumor suppressive adaptive immune response and whether Reg3b can serve as a sensitizer for immune checkpoint blockade.
(Bild: Georg-Speyer-Haus Frankfurt am Main)