Publications

2020:

Induction of regulatory T cells in L. major-infected BALB/c mice does not require Langerin+ dendritic cells
J Invest Dermatol
Dominika Lukas, Kirsten Dietze-Schwonberg, Kordula Kautz-Neu, Beate Lorenz, Nir Yogev, Björn E Clausen and Esther von Stebut

DOI: 10.1016/j.jid.2020.04.033

With contribution of the projects: TP14, TP15


Nano-Enhanced Cancer Immunotherapy: Immunology Encounters Nanotechnology
Cells
Ernesto Bockamp, Sebastian Rosigkeit, Dominik Siegl and Detlef Schuppan

DOI: 10.3390/cells9092102

With contribution of the project: TP08


Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers
Cells
Leonard Kaps and Detlef Schuppan

DOI: 10.3390/cells9092027

With contribution of the project: TP08


Translational Considerations to Improve Response and Overcome Therapy Resistance in Immunotherapy for Hepatocellular Carcinoma
Cancers (Basel)
Sophia Heinrich, Darko Castven, Peter R. Galle and Jens U. Marquardt

DOI: 10.3390/cancers12092495

With contribution of the project: TP07


Supplementary medication in multiple sclerosis: Real-world experience and potential interference with neurofilament light chain measurement
Mult Scler J Exp Transl Clin
Katrin Pape, Falk Steffen, Frauke Zipp and Stefan Bittner

DOI: 10.1177/2055217320936318

With contribution of the project: TP09


Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery
Natalie Fuchs, Mergim Meta, Detlef Schuppan, Lutz Nuhn and Tanja Schirmeister
Cells

DOI: 10.3390/cells9092021

With contribution of the project: TP08


Positive Role of the MHC Class-I Antigen Presentation Regulator m04/gp34 of Murine Cytomegalovirus in Antiviral Protection by CD8 T Cells
Front Cell Infect Microbiol
Sara Becker, Annette Fink, Jürgen Podlech, Irina Giese, Julia K. Schmiedeke, Thomas Bukur, Matthias J. Reddehase and Niels A. Lemmermann

DOI: 10.3389/fcimb.2020.00454

With contribution of the projects: TP11, TPZ01


In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by α-Mannosyl-Functionalized Cationic Nanohydrogel Particles
Cells
Leonard Kaps, Nadine Leber, Adrian Klefenz, Niklas Choteschovsky, Rudolf Zentel, Lutz Nuhn and Detlef Schuppan

DOI: 10.3390/cells9081905

With contribution of the project: TP08


AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer
J Exp Med
Julia Varga, Adele Nicolas, Valentina Petrocelli, Marina Pesic, Abdelrahman Mahmoud, Birgitta E. Michels, Emre Etlioglu, Diego Yepes, Björn Häupl, Paul K. Ziegler, Katrin Bankov, Peter J. Wild, Stefan Wanninger, Hind Medyouf, Henner F. Farin, Sabine Tejpar, Thomas Oellerich, Jürgen Ruland, Christian W. Siebel and Florian R. Greten

DOI: 10.1084/jem.20191515

With contribution of the project: TP16


Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors
Vaccines (Basel)
Rafaela Holtappels, Kirsten Freitag, Angelique Renzaho, Sara Becker, Niels A W Lemmermann and Matthias J Reddehase

DOI: 10.3390/vaccines8030402

With contribution of the projects: TP11, TP14


The non-linearity of RAF-MEK signaling in dendritic cells
Cell Cycle
Kristina Riegel and Krishnaraj Rajalingam

DOI: 10.1080/15384101.2020.1795990

With contribution of the project: TP05


Mast cell-deficiency protects susceptible BALB/c mice from progressive murine cutaneous leishmaniasis
J Invest Dermatol
Kirsten Dietze-Schwonberg, Beate Lorenz, Ann-Kathrin Hartmann, Michael Stassen and Esther von Stebut

DOI: 10.1016/j.jid.2020.06.023

With contribution of the project: TP15


Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier
Acta Neuropathol
Judith Hauptmann, Lisa Johann, Federico Marini, Maja Kitic, Elisa Colombo, Ilgiz A. Mufazalov, Martin Krueger, Khalad Karram, Sonja Moos, Florian Wanke, Florian C. Kurschus, Matthias Klein, Silvia Cardoso, Judith Strauß, Subhashini Bolisetty, Fred Lühder, Markus Schwaninger, Harald Binder, Ingo Bechman, Tobias Bopp, Anupam Agarwal, Miguel P. Soares, Tommy Regen and Ari Waisman

DOI: 10.1007/s00401-020-02187-x

With contribution of the projects: TP01, TP15


A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice
OncoImmunology
Nadja Salomon, Fulvia Vascotto, Abderaouf Selmi, Mathias Vormehr, Juliane Quinkhardt, Thomas Bukur, Barbara Schrörs, Martin Löewer, Mustafa Diken, Özlem Türeci, Ugur Sahin and Sebastian Kreiter

DOI: 10.1080/2162402X.2020.1771925

With contribution of the project: TP17


Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation
Front Cell Infect Microbiol
Emin Gezinir, Jürgen Podlech, Kerstin M. Gergely, Sara Becker, Matthias J. Reddehase and Niels A. W. Lemmermann

DOI: 10.3389/fcimb.2020.00279

With contribution of the project: TP11


A Subset of Flavaglines Inhibits KRAS Nanoclustering and Activation
Journal of Cell Science
Hajime Yurugi, Yinyin Zhuang, Farid A Siddiqui, Hong Liang, Sebastian Rosigkeit, Yongpeng Zeng, Hussein Abou-Hamdan, Ernesto Bockamp, Yong Zhou, Daniel Abankwa, Wenting Zhao, Laurent Désaubry und Krishnaraj Rajalingam

DOI: 10.1242/jcs.244111

With contribution of project: TP05


Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells
Cell
Laura Schaupp, Sabine Muth, Leif Rogell, Michael Kofoed-Branzk, Felix Melchior, Stefan Lienenklaus, Stephanie C. Ganal-Vonarburg, Matthias Klein, Fabian Guendel, Tobias Hain, Kristian Schütze, Ulrike Grundmann, Vanessa Schmitt, Martina Dorsch, Julia Spanier, Pia-Katharina Larsen, Thomas Schwanz, Sven Jäckel, Christoph Reinhardt, Tobias Bopp, Sven Danckwardt, Karsten Mahnke, Gitta Anne Heinz, Mir-Farzin Mashreghi, Pawel Durek, Ulrich Kalinke, Oliver Kretz, Tobias B. Huber, Siegfried Weiss, Christoph Wilhelm, Andrew J. Macpherson, Hansjörg Schild, Andreas Diefenbach and Hans Christian Probst

DOI: 10.1016/j.cell.2020.04.022

With contribution of the projects: TP01, TP13


Type 1 Treg Cells Promote the Generation of CD8 + Tissue-Resident Memory T Cells
Nature Immunology
Cristina Ferreira, Leandro Barros, Marta Baptista, Birte Blankenhaus, André Barros, Patrícia Figueiredo-Campos, Špela Konjar, Alexandra Lainé, Nadine Kamenjarin, Ana Stojanovic, Adelheid Cerwenka, Hans C Probst, Julien C Marie and Marc Veldhoen

DOI: 10.1038/s41590-020-0674-9

With contribution of the project: TP13


Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease
Journal of Molecular Medicine
Emmanuel Pinteaux, Wesam H Abdulaal, Ilgiz A Mufazalov, Neil E Humphreys, Maj Simonsen-Jackson, Sheila Francis, Werner Müller and Ari Waisman

DOI: 10.1007/s00109-020-01928-5

With contribution of the project: TP15


Cytomegalovirus-Associated Inhibition of Hematopoiesis Is Preventable by Cytoimmunotherapy With Antiviral CD8 T Cells
Frontiers in Cellular and Infection Microbiology
Angelique Renzaho, Jürgen Podlech, Birgit Kühnapfel, Franziska Blaum, Matthias J. Reddehase and Niels A. W. Lemmermann

DOI: 10.3389/fcimb.2020.00138

With contribution of the project: TP11


ONX 0914 Lacks Selectivity for the Cardiac Immunoproteasome in Coxsackievirus B3 Myocarditis of NMRI Mice and Promotes Virus-Mediated Tissue Damage
Cells
Hannah Louise Neumaier, Shelly Harel, Karin Klingel, Ziya Kaya, Arnd Heuser, Meike Kespohl and Antje Beling

DOI: 10.3390/cells9051093

With contribution of the project: TP02


Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation
Frontiers in Cellular and Infection Microbiology
Rafaela Holtappels, Sina I. Schader, Oliver Oettel, Jürgen Podlech, Christof K. Seckert, Matthias J. Reddehase and Niels A. W. Lemmermann

DOI: 10.3389/fcimb.2020.00157

With contribution of the projects: TP11, TP14


Tunneling Nanotubes and Tumor Microtubes in Cancer
Cancers (Basel)
Cora Roehlecke and Mirko H. H. Schmidt

DOI: 10.3390/cancers12040857

With contribution of the project: TP09


Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
Nature Communications
Aswini Krishnan, Jean Berthelet, Emilie Renaud, Sebastian Rosigkeit, Ute Distler, Eric Stawiski, Jing Wang, Zora Modrusan, Marc Fiedler, Mariann Blienz, Stefan Tenzer, Arno Schad, Wilfried Roth, Bernd Thiede, Somasekar Seshagiri, Thomas J. Musholt and Krishnaraj Rajalingam

DOI: 10.1038/s41467-020-15955-w

With contribution of the projects: TP05, TPZ01


ERK3/MAPK6 controls IL-8 production and chemotaxis
eLife
Katarzyna Bogucka, Malvika Pompaiah, Federico Marini, Harald Binder, Gregory Harms, Manuel Kaulich, Matthias Klein, Christian Michel, Markus P Radsak, Sebastian Rosigkeit, Peter Grimminger, Hansjörg Schild and Krishnaraj Rajalingam

DOI: 10.7554/eLife.52511

With contribution of the projects: TP05, TP01, TP13


Microenvironmental Th9– and Th17– lymphocytes induce metastatic spreading in lung cancer
Journal of Clinical Investigation
Ylia Salazar, Xiang Zheng, David Brunn, Hartmann Raifer, Felix S.R. Picard, Yajuan Zhang, Hauke Winter, Stefan Günther, Andreas Weigert, Benno Weigmann, Laure Dumoutier, Jean-Christophe Renauld, Ari Waisman, Anja Schmall, Amanda Tufman, Ludger Fink, Bernhard Brüne, Tobias Bopp, Friedrich Grimminger, Werner Seeger, Soni Savai Pullamsetti, Magdalena Huber and Rajkumar Savai

DOI: 10.1172/JCI124037

With contribution of the projects: TP01,TP15


Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
Nature Communications
Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer, Burkhard Kleuser, Eduard B. Babiychuk, Beate Sodeik, Jürgen Seibel, Urs F. Greber, Philipp A. Lang, Erich Gulbins and Karl S. Lang

DOI:10.1038/s41467-020-15072-8

With contribution of the project: TP13


CNS-localized myeloid cells capture living invading T cells during neuroinflammation
Journal of Experimental Medicine
Beatrice Wasser, Dirk Luchtmann, Julian Löffel, Kerstin Robohm, Katharina Birkner, Albrecht Stroh, Christina Franzisca Vogelaar, Frauke Zipp and Stefan Bittner

DOI: 10.1084/jem.20190812

With contribution of the project: TP09


β-arrestin: Dr Jekyll and Mr Hyde in NASH and fibrosis
Journal of Hepatology
Hiroyuki Abe and Detlef Schuppan

DOI:10.1016/j.jhep.2020.01.016

With contribution of the project: TP08


Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases
Cellular and Molecular Life Sciences
Dong Wang, Redouane Tabti, Sabria Elderwish, Hussein Abou‑Hamdan, Amel Djehal, Peng Yu, Hajime Yurugi, Krishnaraj Rajalingam, Canan G. Nebigil and Laurent Désaubry

DOI: 10.1007/s00018-020-03475-1

With contribution of the project: TP05


Heart-Specific Immune Responses in an Animal Model of AutoimmuneRelated Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation
Circulation
Mariella Bockstahler, Andrea Fischer, Carl Christoph Goetzke, Hannah Louise Neumaier, Martina Sauter, Meike Kespohl, Anna-Maria Müller, Christin Meckes, Christian Salbach, Mirjam Schenk, Arnd Heuser, Ulf Landmesser, January Weiner, Benjamin Meder, Lorenz Lehmann, Adelheid Kratzer, Karin Klingel, Hugo A Katus, Ziya Kaya and Antje Beling

DOI: 10.1161/CIRCULATIONAHA.119.043171

With contribution of the project: TP02


Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain
Cells
Ute Distler, Sven Schumann, Hans-Georg Kesseler, Rainer Pielot, Karl-Heinz Smalla, Malte Sielaff, Michael J Schmeisser and Stefan Tenzer

DOI: 10.3390/cells9020313

With contribution of the project: TPZ01


High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia
Frontiers in Immunology
Stephan Müller, Tobias Bexte, Veronika Gebel, Franziska Kalensee, Eva Stolzenberg, Jessica Hartmann, Ulrike Koehl, Axel Schambach, Winfried S. Wels, Ute Modlich and Evelyn Ullrich

DOI: 10.3389/fimmu.2019.03123

With contribution of the project: TP12


Investigating fibrosis and inflammation in an ex vivo NASH murine model
American Journal of Gastrointestinal and Liver Physiology
Emilia Gore, Emilia Bigaeva, Anouk Oldenburger, Yvette J. M. Jansen, Detlef Schuppan, Miriam Boersema, Jörg F. Rippmann, Andre Broermann and Peter Olinga

DOI: 10.1152/ajpgi.00209.2019

With contribution of the project: TP08


Monocentric experiences of stereotactic body radiation therapy (SBRT) for advanced hepatocellular carcinomas (BCLC-C)
Zeitschrift für Gastroenterologie
Carolin Czauderna, Marcus Stockinger, Anne Ebersberger, Heinz Schmidberger, Lukas Müller, Roman Kloeckner, Christoph Düber, Arndt Weinmann, Peter R. Galle and Jens U. Marquardt

DOI: 10.1055/a-1072-6683

With contribution of the project: TP07


2019:

Poor transcript‐protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause
Journal of Neurochemistry
Christian P. Moritz, Timo Mühlhaus, Stefan Tenzer, Thomas Schulenborg and Eckhard Friauf

DOI: 10.1111/jnc.14664

With contribution of the project: TPZ01


The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Nature Reviews Gastroenterology & Hepatology
Konstantin Kazankov, Simon Mark Dahl Jørgensen, Karen Louise Thomsen, Holger Jon Møller, Hendrik Vilstrup, Jacob George, Detlef Schuppan and Henning Grønbæk

DOI: 10.1038/s41575-018-0082-x

With contribution of the project: TP08


Enhancing Sensitivity of Microflow-Based Bottom-Up Proteomics through Postcolumn Solvent Addition
Analytical Chemistry
Ute Distler, Mateusz Krzysztof Łącki, Sven Schumann, Markus Wanninger and Stefan Tenzer

DOI: 10.1021/acs.analchem.9b00118

With contribution of the project: TPZ01


Context-Dependent Role of NF-κB Signaling in Primary Liver Cancer — from Tumor Development to Therapeutic Implications
Cancers
Carolin Czauderna, Darko Castven, Friederike L. Mahn and Jens U. Marquardt

DOI: 10.3390/cancers11081053

With contribution of the project: TP07


Transcutaneous immunization with CD40 ligation boosts cytotoxic T lymphocyte mediated antitumor immunity independent of CD4 helper cells in mice
European Journal of Immunology
Ariane Bialojan, Julian Sohl, Johanna Rausch, Pamela Aranda Lopez, Mark Denny, Peter Langguth, Ann‐Kathrin Hartmann, Hideo Yagita, Hans Christian Probst, Hansjörg Schild and Markus P. Radsak

DOI: 10.1002/eji.201848039

With contribution of the project: TP13


Myeloid cell-synthesized coagulation Factor X dampens anti-tumor immunity
Science Immunology
Claudine Graf, Petra Wilgenbus, Sven Pagel, Jennifer Pott, Federico Marini, Sabine Reyda, Maki Kitano, Stephan Macher-Göppinger, Hartmut Weiler and Wolfram Ruf

DOI: 10.1126/sciimmunol.aaw8405

With contribution of the project: TP10


PI3K inhibition reduces murine and human liver fibrogenesis in precision-cut liver slices
Biochemical Pharmacology
Emilia Gorea, Emilia Bigaeva, Anouk Oldenburger, Yong Ook Kim, Jörg F. Rippmann, Detlef Schuppan, Miriam Boersema and Peter Olinga

DOI: 10.1016/j.bcp.2019.113633

With contribution of the project: TP08


Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer
American Journal of Physiology - Gastrointestinal and Liver Physiology
Guangyan Wei, Ping An, Kahini A. Vaid, Imad Nasser, Pinzhu Huang, Li Tan, Shuangshuang Zhao, Detlef Schuppan and Yury V. Popov

DOI: 10.1152/ajpgi.00041.2019

With contribution of the project: TP08


Early Treatment of Coxsackievirus B3–Infected Animals With Soluble Coxsackievirus-Adenovirus Receptor Inhibits Development of Chronic Coxsackievirus B3 Cardiomyopathy
Circulation Heart Failure
Sandra Pinkert, Babette Dieringer, Robert Klopfleisch, Konstantinos Savvatis, Sophie Van Linthout, Markian Pryshliak, Carsten Tschöpe, Karin Klingel, Jens Kurreck, Antje Beling and Henry Fechner

DOI: 10.1161/CIRCHEARTFAILURE.119.005250

With contribution of the project: TP02


Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability
Frontiers in Oncology
Anke Werner, Daniel Pieh, Hakim Echchannaoui, Johanna Rupp, Krishnaraj Rajalingam, Matthias Theobald, Ellen I. Closs and Markus Munder

DOI: 10.3389/fonc.2019.01268

With contribution of the projects: TP05, TP06


Predisposition to Apoptosis in Hepatocellular Carcinoma: From Mechanistic Insights to Therapeutic Strategies
Frontiers in Oncology
Jens U. Marquardt and Frank Edlich

DOI: 10.3389/fonc.2019.01421

With contribution of the project: TP07


Myeloid cell–synthesized coagulation factor X dampens antitumor immunity
Science Immunology
Claudine Graf, Petra Wilgenbus, Sven Pagel, Jennifer Pott, Federico Marini, Sabine Reyda, Maki Kitano, Stephan Macher-Göppinger, Hartmut Weiler and Wolfram Ruf;

DOI:10.1126/sciimmunol.aaw8405

With contribution of the project: TP10


Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
Cell Reports
Kathrin Renner, Christina Bruss, Annette Schnell, Gudrun Koehl, Holger M. Becker, Matthias Fante, Ayse-Nur Menevse, Nathalie Kauer, Raquel Blazquez, Lisa Hacker, Sonja-Maria Decking, Toszka Bohn, Stephanie Faerber, Katja Evert, Lisa Aigle, Sabine Amslinger, Maria Landa, Oscar Krijgsman, Elisa A. Rozeman, Christina Brummer, Peter J. Siska, Katrin Singer, Stefanie Pektor, Matthias Miederer, Katrin Peter, Eva Gottfried, Wolfgang Herr, Ibtisam Marchiq, Jacques Pouyssegur, William R. Roush, SuFey Ong, Sarah Warren, Tobias Pukrop, Philipp Beckhove, Sven A. Lang, Tobias Bopp, Christian U. Blank, John L. Cleveland, Peter J. Oefner, Katja Dettmer, Mark Selby and Marina Kreutz

DOI: 10.1016/j.celrep.2019.08.068

With contribution of the project: TP01


Pan-RTK activity of soluble LRIG1 mediates AXL downregulation in glioblastoma
Neuro-Oncology Advances
Virginie Neirinckx, Ann-Christin Hau, Anne Schuster, Sabrina Fritah, Katja Tiemann, Petr V. Nazarov, André Matagne, Martyna Szpakowska, Max Meyrath, Andy Chevigné, Mirko HH Schmidt, Simone P. Niclou

DOI: 10.1093/noajnl/vdz024

With contribution of the project: TP09


The role of SVZ stem cells in glioblastoma
Cancers
Christina Altmann, Stefanie Keller & Mirko HH Schmidt

DOI: 10.3390/cancers11040448

With contribution of the project: TP09


RAF kinases are stabilized and required for dendritic cell differentiation and function
Cell Death & Differentiation
Kristina Riegel, Janine Schlöder, Marco Sobczak, Helmut Jonuleit, Bernd Thiede, Hansjörg Schild & Krishnaraj Rajalingam

DOI: 10.1038/s41418-019-0416-4

With contribution of the projects: TP05, TP13


Trends and challenges in tumor anti-angiogenic therapies
Cells
József Jászai, Mirko HH Schmidt

DOI: 10.3390/cells8091102

With contribution of the project: TP09


Humanized mice in cutaneous leishmaniasis-Suitability analysis of human PBMC transfer into immunodeficient mice
Experimental Dermatology
Michael R Fischer, Anja I Schermann, Trix Twelkmeyer, Beate Lorenz, Joanna Wegner, Helmut Jonuleit, Esther von Stebut

DOI: 10.1111/exd.13999

With contribution of the project: TP15


IL-17A/F in Leishmania major-resistant C57BL/6 mice
Experimental Dermatology
Kirsten Dietze‐Schwonberg, Susanna Lopez Kostka, Beate Lorenz, Tommy Regen, Ari Waisman, Esther von Stebut

DOI: 10.1111/exd.13896

With contribution of the project: TP15


Langerin+CD8+ dendritic cells in the splenic marginal zone: not so marginal after all.
Frontiers in Immunology
Ronald A Backer, Nathalie Diener, Björn E Clausen
DOI: 10.3389/fimmu.2019.00741

With contribution of the project: TP14


Adverse immunological imprinting by cytomegalovirus sensitizing for allergic airway disease
Medical Microbiology and Immunology
Matthias J Reddehase
DOI: 10.1007/s00430-019-00610-z.

With contribution of the project: TP11


Pediatric roots of cytomegalovirus recurrence and memory inflation in the elderly
Medical Microbiology and Immunology
Stuart P Adler, Matthias J Reddehase
DOI: 10.1007/s00430-019-00609-6

With contribution of the project: TP11


Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' résumé
Medical Microbiology and Immunology
Astrid Krmpotić A, Jürgen Podlech, Matthias J Reddehase, William J Britt, Stipan Jonjić
DOI: 10.1007/s00430-019-00600-1

With contribution of the project: TP11


Cellular reservoirs of latent cytomegaloviruses
Medical Microbiology and Immunology
Matthias J Reddehase, Niels A Lemmermann
DOI: 10.1007/s00430-019-00592-y.

With contribution of the project: TP11


Inflammation and cancer: triggers, mechanisms, and consequences
Immunity
Florian R Greten, Sergei I Grivennikov
DOI: 10.1016/j.immuni.2019.06.025

With contribution of the project: TP16


Modulating inflammation for cancer therapy
Journal of Experimental Medicine
Birgit Ritter, Florian R Greten
DOI: 10.1084/jem.20181739

With contribution of the project: TP16


Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis
Oncogene
Tiago De Oliveira, Mallika Ramakrishnan, Michaela A. Diamanti, Paul K. Ziegler, Frank Brombacher, Florian R. Greten
DOI: 10.1038/s41388-018-0551-2

With contribution of the project: TP16


ISG15 deficiency enhances HIV-1 infection by accumulating misfolded p53
mBio
Edmund Osei Kuffour, Renate König, Dieter Häussinger, Wolfgang A. Schulz, Carsten Münk
DOI: 10.1128/mBio.01342-19.

With contribution of the project: TP04


Intertwined: SAMHD1 cellular functions, restriction, and viral evasion strategies
Medical Microbiology and Immunology
Catharina Majer, Jan Moritz Schüssler, Renate König
DOI: 10.1007/s00430-019-00593-x

With contribution of the project: TP04


Function of the cargo sorting dileucine motif in a cytomegalovirus immune evasion protein
Medical Microbiology and Immunology
Anette Fink, Snježana Mikuličić, Franziska Blaum, Mathias J Reddehase, Luise Florin, Niels A Lemmermann
DOI: 10.1007/s00430-019-00604-x

With contribution of the project: TP11


A potent tumor-reactive p53-specific single-chain TCR without on- or off-target autoimmunity in vivo Molecular Therapy
Hakim Echchannaoui, Jutta Petschenka, Edite Antunes Ferreira, Beate Hauptrock Carina Lotz-Jenne, Ralf-Holger Voss, Matthias Theobald
DOI: 10.1016/j.ymthe.2018.11.00

With contribution of the project: TP06


Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells
PLoS Pathogens
Sebastian Reuter, Niels A Lemmermann, Joachim Maxeiner, Jürgen Podlech, Hendrik Beckert, Kirsten Freitag, Daniel Teschner, Frederic Ries, Christian Taube, Roland Buhl, Matthias J. Reddehase, Rafaela Holtappels
DOI: 10.1371/journal.ppat.1007595

With contribution of the projects: TP11, TP14


The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection
Markus Stempel, Baca Chan, Vanda Juranić Lisnić, Astrid Krmpotić, Josephine Hartung, Søren R Paludan, Nadia Füllbrunn, Niels A Lemmermann, Melanie M Brinkmann.
EMBO Journal
DOI: 10.15252/embj.2018100983

With contribution of the project: TP11


Transcripts expressed in cytomegalovirus latency coding for an antigenic IE/E phase peptide that drives "memory inflation"
Medical Microbiology and Immunology
Angelique Renzaho, Julia K Schmiedeke, Marion Griessl, Birgit Kühnapfel, Christof K, Niels A Lemmermann
DOI: 10.1007/s00430-019-00615-8

With contribution of the project: TP11


2018:

Tissue factor as a mediator of coagulation and signaling in cancer and chronic inflammation
Thrombosis Research
Claudine Graf and Wolfram Ruf

DOI:10.1016/j.thromres.2018.01.023

With contribution of the project: TP10


Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune
Myocarditis

Frontiers in Immunology
Ingmar Sören Meyer, Carl Christoph Goetzke, Meike Kespohl, Martina Sauter, Arnd Heuser, Volker Eckstein, Hans-Peter Vornlocher, Daniel G. Anderson, Jan Haas, Benjamin Meder, Hugo Albert Katus, Karin Klingel, Antje Beling and Florian Leuschner

DOI: 10.3389/fimmu.2018.02303

With contribution of the project: TP02


Proteasomal Protein Degradation: Adaptation of Cellular Proteolysis With Impact on Virus—and Cytokine-Mediated Damage of Heart Tissue During Myocarditis
Frontiers in Immunology
Antje Beling and Meike Kespohl

DOI: 10.3389/fimmu.2018.02620

With contribution of the project: TP02


Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
Nature Immunology
Toszka Bohn, Steffen Rapp, Natascha Luther, Matthias Klein, Till-Julius Bruehl, Nobuhiko Kojima, Pamela Aranda Lopez, Jennifer Hahlbrock, Sabine Muth, Shogo Endo, Stefanie Pektor, Almut Brand, Kathrin Renner, Vanessa Popp, Katharina Gerlach, Dennis Vogel, Christina Lueckel, Danielle Arnold-Schild, Jacques Pouyssegur, Marina Kreutz, Magdalena Huber, Jochem Koenig, Benno Weigmann, Hans-Christian Probst, Esther von Stebut, Christian Becker, Hansjoerg Schild, Edgar Schmitt, Tobias Bopp

With contribution of the projects: TP1, TP13, TP15


Fungi enter the stage of colon carcinogenesis
Immunity
Claire Conche, Florian R Greten
DOI: 10.1016/j.immuni.2018.09.002.

With contribution of the project: TP16


Mitophagy in intestinal epithelial cells triggers adaptive immunity during tumorigenesis
Cell
Paul K Ziegler, Julia Bollrath, Charles K Pallangyo, Takaji Matsutani, Özge Canli, Tiago De Oliveira, Michaela A Diamanti, Nina Müller, Jaba Gamrekelashvili, Tracy Putoczki, David Horst, Arun K Mankan, Meryem G Öner, Susanna Müller, Josef Müller-Höcker, Thomas Kirchner, Julia Slotta-Huspenina, M. Mark Taketo, Thomas Reinheckel, Stefan Dröse, Andrew C Larner, Winfried S Wels, Matthias Ernst, Tim F Greten, Melek C Arkan, Thomas Korn, Dagmar Wirth, Florian R Greten
DOI: 10.1016/j.cell.2018.05.028

With contribution of the project: TP16


USP18 (UBP43) abrogates p21-mediated inhibition of HIV-1
Journal of Virology
Edmund Osei Kuffour, Kerstin Schott, Ananda Ayyappan Jaguva Vasudevan, Jessica Holler, Wolfgang A. Schulz, Philipp A Lang, Karl S Lang, Baek Kim, Dieter Häussinger, Renate König, Carsten Münk
DOI: 10.1128/JVI.00592-18.

With contribution of the project: TP04


The Myb-related protein MYPOP is a novel intrinsic host restriction factor of oncogenic human papillomaviruses
Oncogene
Elena Wüstenhagen, Fatima Boukhallouk, Inka Negwer, Krishnaraj Rajalingam, Frank Stubenrauch, Luise Florin
DOI: 10.1038/s41388-018-0398-6

With contribution of the project: TP05


Mouse model of cytomegalovirus disease and immunotherapy in the immunocompromised host: predictions for medical translation that survived the "Test of Time"
Viruses
Matthias J Reddehase, Niels A Lemmermann
DOI: 10.3390/v10120693.

With contribution of the project: TP11


Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity
EMBO Journal
Ulrike Buehler, Katharina Schulenburg, Hajime Yurugi, Maja Šolman, Daniel Abankwa, Alexander Ulges, Stefan Tenzer, Tobias Bopp, Bernd Thiede, Frauke Zipp, Krishnaraj Rajalingam
DOI: 10.15252/embj.201899429

With contribution of the projects: TP05, TP09, TP01, Z01


EGFL7 enhances surface expression of integrin α5β1to promote angiogenesis in malignant brain tumors
EMBO Molecular Medicine
Nevenka Dudvarski Stanković, Frank Bicker, Stefanie Keller, David TW Jones, Patrick N Harter, Arne Kienzle, Clarissa Gillmann, Philipp Arnold, Anna Golebiewska, Olivier Keunen, Alf Giese, Andreas von Deimling, Tobias Bäuerle, Simone P Niclou, Michel Mittelbronn, Weilan Ye, Stefan M Pfister, Mirko HH Schmidt
DOI 10.15252/emmm.201708420

With contribution of the project: TP09


Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
Nature Communications
Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens & Renate König
DOI:10.1038/s41467-018-04671-1

With contribution of the project: TP04


Efficient delivery of human cytomegalovirus T cell antigens by attenuated Sendai virus vectors
Journal of Virology
Richard Kiener, Markus Fleischmann, Marian Alexander Wiegand, Niels A. W. Lemmermann, Christiane Schwegler, Christine Kaufmann, Angelique Renzaho, Simone Thomas, Eva Felder, Hans Helmut Niller, Benedikt Asbach, Ralf Wagner
DOI:10.1128/JVI.00569-18

With contribution of the project: TP11