2020:
Induction of regulatory T cells in L. major-infected BALB/c mice does not require Langerin+ dendritic cells
J Invest Dermatol
Dominika Lukas, Kirsten Dietze-Schwonberg, Kordula Kautz-Neu, Beate Lorenz, Nir Yogev, Björn E Clausen and Esther von Stebut
DOI: 10.1016/j.jid.2020.04.033
With contribution of the projects: TP14, TP15
Nano-Enhanced Cancer Immunotherapy: Immunology Encounters Nanotechnology
Cells
Ernesto Bockamp, Sebastian Rosigkeit, Dominik Siegl and Detlef Schuppan
DOI: 10.3390/cells9092102
With contribution of the project: TP08
Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers
Cells
Leonard Kaps and Detlef Schuppan
DOI: 10.3390/cells9092027
With contribution of the project: TP08
Translational Considerations to Improve Response and Overcome Therapy Resistance in Immunotherapy for Hepatocellular Carcinoma
Cancers (Basel)
Sophia Heinrich, Darko Castven, Peter R. Galle and Jens U. Marquardt
DOI: 10.3390/cancers12092495
With contribution of the project: TP07
Supplementary medication in multiple sclerosis: Real-world experience and potential interference with neurofilament light chain measurement
Mult Scler J Exp Transl Clin
Katrin Pape, Falk Steffen, Frauke Zipp and Stefan Bittner
DOI: 10.1177/2055217320936318
With contribution of the project: TP09
Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery
Natalie Fuchs, Mergim Meta, Detlef Schuppan, Lutz Nuhn and Tanja Schirmeister
Cells
DOI: 10.3390/cells9092021
With contribution of the project: TP08
Positive Role of the MHC Class-I Antigen Presentation Regulator m04/gp34 of Murine Cytomegalovirus in Antiviral Protection by CD8 T Cells
Front Cell Infect Microbiol
Sara Becker, Annette Fink, Jürgen Podlech, Irina Giese, Julia K. Schmiedeke, Thomas Bukur, Matthias J. Reddehase and Niels A. Lemmermann
DOI: 10.3389/fcimb.2020.00454
With contribution of the projects: TP11, TPZ01
In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by α-Mannosyl-Functionalized Cationic Nanohydrogel Particles
Cells
Leonard Kaps, Nadine Leber, Adrian Klefenz, Niklas Choteschovsky, Rudolf Zentel, Lutz Nuhn and Detlef Schuppan
DOI: 10.3390/cells9081905
With contribution of the project: TP08
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer
J Exp Med
Julia Varga, Adele Nicolas, Valentina Petrocelli, Marina Pesic, Abdelrahman Mahmoud, Birgitta E. Michels, Emre Etlioglu, Diego Yepes, Björn Häupl, Paul K. Ziegler, Katrin Bankov, Peter J. Wild, Stefan Wanninger, Hind Medyouf, Henner F. Farin, Sabine Tejpar, Thomas Oellerich, Jürgen Ruland, Christian W. Siebel and Florian R. Greten
DOI: 10.1084/jem.20191515
With contribution of the project: TP16
Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors
Vaccines (Basel)
Rafaela Holtappels, Kirsten Freitag, Angelique Renzaho, Sara Becker, Niels A W Lemmermann and Matthias J Reddehase
DOI: 10.3390/vaccines8030402
With contribution of the projects: TP11, TP14
The non-linearity of RAF-MEK signaling in dendritic cells
Cell Cycle
Kristina Riegel and Krishnaraj Rajalingam
DOI: 10.1080/15384101.2020.1795990
With contribution of the project: TP05
Mast cell-deficiency protects susceptible BALB/c mice from progressive murine cutaneous leishmaniasis
J Invest Dermatol
Kirsten Dietze-Schwonberg, Beate Lorenz, Ann-Kathrin Hartmann, Michael Stassen and Esther von Stebut
DOI: 10.1016/j.jid.2020.06.023
With contribution of the project: TP15
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier
Acta Neuropathol
Judith Hauptmann, Lisa Johann, Federico Marini, Maja Kitic, Elisa Colombo, Ilgiz A. Mufazalov, Martin Krueger, Khalad Karram, Sonja Moos, Florian Wanke, Florian C. Kurschus, Matthias Klein, Silvia Cardoso, Judith Strauß, Subhashini Bolisetty, Fred Lühder, Markus Schwaninger, Harald Binder, Ingo Bechman, Tobias Bopp, Anupam Agarwal, Miguel P. Soares, Tommy Regen and Ari Waisman
DOI: 10.1007/s00401-020-02187-x
With contribution of the projects: TP01, TP15
A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice
OncoImmunology
Nadja Salomon, Fulvia Vascotto, Abderaouf Selmi, Mathias Vormehr, Juliane Quinkhardt, Thomas Bukur, Barbara Schrörs, Martin Löewer, Mustafa Diken, Özlem Türeci, Ugur Sahin and Sebastian Kreiter
DOI: 10.1080/2162402X.2020.1771925
With contribution of the project: TP17
Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation
Front Cell Infect Microbiol
Emin Gezinir, Jürgen Podlech, Kerstin M. Gergely, Sara Becker, Matthias J. Reddehase and Niels A. W. Lemmermann
DOI: 10.3389/fcimb.2020.00279
With contribution of the project: TP11
A Subset of Flavaglines Inhibits KRAS Nanoclustering and Activation
Journal of Cell Science
Hajime Yurugi, Yinyin Zhuang, Farid A Siddiqui, Hong Liang, Sebastian Rosigkeit, Yongpeng Zeng, Hussein Abou-Hamdan, Ernesto Bockamp, Yong Zhou, Daniel Abankwa, Wenting Zhao, Laurent Désaubry und Krishnaraj Rajalingam
DOI: 10.1242/jcs.244111
With contribution of project: TP05
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells
Cell
Laura Schaupp, Sabine Muth, Leif Rogell, Michael Kofoed-Branzk, Felix Melchior, Stefan Lienenklaus, Stephanie C. Ganal-Vonarburg, Matthias Klein, Fabian Guendel, Tobias Hain, Kristian Schütze, Ulrike Grundmann, Vanessa Schmitt, Martina Dorsch, Julia Spanier, Pia-Katharina Larsen, Thomas Schwanz, Sven Jäckel, Christoph Reinhardt, Tobias Bopp, Sven Danckwardt, Karsten Mahnke, Gitta Anne Heinz, Mir-Farzin Mashreghi, Pawel Durek, Ulrich Kalinke, Oliver Kretz, Tobias B. Huber, Siegfried Weiss, Christoph Wilhelm, Andrew J. Macpherson, Hansjörg Schild, Andreas Diefenbach and Hans Christian Probst
DOI: 10.1016/j.cell.2020.04.022
With contribution of the projects: TP01, TP13
Type 1 Treg Cells Promote the Generation of CD8 + Tissue-Resident Memory T Cells
Nature Immunology
Cristina Ferreira, Leandro Barros, Marta Baptista, Birte Blankenhaus, André Barros, Patrícia Figueiredo-Campos, Špela Konjar, Alexandra Lainé, Nadine Kamenjarin, Ana Stojanovic, Adelheid Cerwenka, Hans C Probst, Julien C Marie and Marc Veldhoen
DOI: 10.1038/s41590-020-0674-9
With contribution of the project: TP13
Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease
Journal of Molecular Medicine
Emmanuel Pinteaux, Wesam H Abdulaal, Ilgiz A Mufazalov, Neil E Humphreys, Maj Simonsen-Jackson, Sheila Francis, Werner Müller and Ari Waisman
DOI: 10.1007/s00109-020-01928-5
With contribution of the project: TP15
Cytomegalovirus-Associated Inhibition of Hematopoiesis Is Preventable by Cytoimmunotherapy With Antiviral CD8 T Cells
Frontiers in Cellular and Infection Microbiology
Angelique Renzaho, Jürgen Podlech, Birgit Kühnapfel, Franziska Blaum, Matthias J. Reddehase and Niels A. W. Lemmermann
DOI: 10.3389/fcimb.2020.00138
With contribution of the project: TP11
ONX 0914 Lacks Selectivity for the Cardiac Immunoproteasome in Coxsackievirus B3 Myocarditis of NMRI Mice and Promotes Virus-Mediated Tissue Damage
Cells
Hannah Louise Neumaier, Shelly Harel, Karin Klingel, Ziya Kaya, Arnd Heuser, Meike Kespohl and Antje Beling
DOI: 10.3390/cells9051093
With contribution of the project: TP02
Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation
Frontiers in Cellular and Infection Microbiology
Rafaela Holtappels, Sina I. Schader, Oliver Oettel, Jürgen Podlech, Christof K. Seckert, Matthias J. Reddehase and Niels A. W. Lemmermann
DOI: 10.3389/fcimb.2020.00157
With contribution of the projects: TP11, TP14
Tunneling Nanotubes and Tumor Microtubes in Cancer
Cancers (Basel)
Cora Roehlecke and Mirko H. H. Schmidt
DOI: 10.3390/cancers12040857
With contribution of the project: TP09
Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
Nature Communications
Aswini Krishnan, Jean Berthelet, Emilie Renaud, Sebastian Rosigkeit, Ute Distler, Eric Stawiski, Jing Wang, Zora Modrusan, Marc Fiedler, Mariann Blienz, Stefan Tenzer, Arno Schad, Wilfried Roth, Bernd Thiede, Somasekar Seshagiri, Thomas J. Musholt and Krishnaraj Rajalingam
DOI: 10.1038/s41467-020-15955-w
With contribution of the projects: TP05, TPZ01
ERK3/MAPK6 controls IL-8 production and chemotaxis
eLife
Katarzyna Bogucka, Malvika Pompaiah, Federico Marini, Harald Binder, Gregory Harms, Manuel Kaulich, Matthias Klein, Christian Michel, Markus P Radsak, Sebastian Rosigkeit, Peter Grimminger, Hansjörg Schild and Krishnaraj Rajalingam
DOI: 10.7554/eLife.52511
With contribution of the projects: TP05, TP01, TP13
Microenvironmental Th9– and Th17– lymphocytes induce metastatic spreading in lung cancer
Journal of Clinical Investigation
Ylia Salazar, Xiang Zheng, David Brunn, Hartmann Raifer, Felix S.R. Picard, Yajuan Zhang, Hauke Winter, Stefan Günther, Andreas Weigert, Benno Weigmann, Laure Dumoutier, Jean-Christophe Renauld, Ari Waisman, Anja Schmall, Amanda Tufman, Ludger Fink, Bernhard Brüne, Tobias Bopp, Friedrich Grimminger, Werner Seeger, Soni Savai Pullamsetti, Magdalena Huber and Rajkumar Savai
DOI: 10.1172/JCI124037
With contribution of the projects: TP01,TP15
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
Nature Communications
Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer, Burkhard Kleuser, Eduard B. Babiychuk, Beate Sodeik, Jürgen Seibel, Urs F. Greber, Philipp A. Lang, Erich Gulbins and Karl S. Lang
DOI:10.1038/s41467-020-15072-8
With contribution of the project: TP13
CNS-localized myeloid cells capture living invading T cells during neuroinflammation
Journal of Experimental Medicine
Beatrice Wasser, Dirk Luchtmann, Julian Löffel, Kerstin Robohm, Katharina Birkner, Albrecht Stroh, Christina Franzisca Vogelaar, Frauke Zipp and Stefan Bittner
DOI: 10.1084/jem.20190812
With contribution of the project: TP09
β-arrestin: Dr Jekyll and Mr Hyde in NASH and fibrosis
Journal of Hepatology
Hiroyuki Abe and Detlef Schuppan
DOI:10.1016/j.jhep.2020.01.016
With contribution of the project: TP08
Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases
Cellular and Molecular Life Sciences
Dong Wang, Redouane Tabti, Sabria Elderwish, Hussein Abou‑Hamdan, Amel Djehal, Peng Yu, Hajime Yurugi, Krishnaraj Rajalingam, Canan G. Nebigil and Laurent Désaubry
DOI: 10.1007/s00018-020-03475-1
With contribution of the project: TP05
Heart-Specific Immune Responses in an Animal Model of AutoimmuneRelated Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation
Circulation
Mariella Bockstahler, Andrea Fischer, Carl Christoph Goetzke, Hannah Louise Neumaier, Martina Sauter, Meike Kespohl, Anna-Maria Müller, Christin Meckes, Christian Salbach, Mirjam Schenk, Arnd Heuser, Ulf Landmesser, January Weiner, Benjamin Meder, Lorenz Lehmann, Adelheid Kratzer, Karin Klingel, Hugo A Katus, Ziya Kaya and Antje Beling
DOI: 10.1161/CIRCULATIONAHA.119.043171
With contribution of the project: TP02
Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain
Cells
Ute Distler, Sven Schumann, Hans-Georg Kesseler, Rainer Pielot, Karl-Heinz Smalla, Malte Sielaff, Michael J Schmeisser and Stefan Tenzer
DOI: 10.3390/cells9020313
With contribution of the project: TPZ01
High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia
Frontiers in Immunology
Stephan Müller, Tobias Bexte, Veronika Gebel, Franziska Kalensee, Eva Stolzenberg, Jessica Hartmann, Ulrike Koehl, Axel Schambach, Winfried S. Wels, Ute Modlich and Evelyn Ullrich
DOI: 10.3389/fimmu.2019.03123
With contribution of the project: TP12
Investigating fibrosis and inflammation in an ex vivo NASH murine model
American Journal of Gastrointestinal and Liver Physiology
Emilia Gore, Emilia Bigaeva, Anouk Oldenburger, Yvette J. M. Jansen, Detlef Schuppan, Miriam Boersema, Jörg F. Rippmann, Andre Broermann and Peter Olinga
DOI: 10.1152/ajpgi.00209.2019
With contribution of the project: TP08
Monocentric experiences of stereotactic body radiation therapy (SBRT) for advanced hepatocellular carcinomas (BCLC-C)
Zeitschrift für Gastroenterologie
Carolin Czauderna, Marcus Stockinger, Anne Ebersberger, Heinz Schmidberger, Lukas Müller, Roman Kloeckner, Christoph Düber, Arndt Weinmann, Peter R. Galle and Jens U. Marquardt
DOI: 10.1055/a-1072-6683
With contribution of the project: TP07
2019:
Poor transcript‐protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause
Journal of Neurochemistry
Christian P. Moritz, Timo Mühlhaus, Stefan Tenzer, Thomas Schulenborg and Eckhard Friauf
DOI: 10.1111/jnc.14664
With contribution of the project: TPZ01
The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Nature Reviews Gastroenterology & Hepatology
Konstantin Kazankov, Simon Mark Dahl Jørgensen, Karen Louise Thomsen, Holger Jon Møller, Hendrik Vilstrup, Jacob George, Detlef Schuppan and Henning Grønbæk
DOI: 10.1038/s41575-018-0082-x
With contribution of the project: TP08
Enhancing Sensitivity of Microflow-Based Bottom-Up Proteomics through Postcolumn Solvent Addition
Analytical Chemistry
Ute Distler, Mateusz Krzysztof Łącki, Sven Schumann, Markus Wanninger and Stefan Tenzer
DOI: 10.1021/acs.analchem.9b00118
With contribution of the project: TPZ01
Context-Dependent Role of NF-κB Signaling in Primary Liver Cancer — from Tumor Development to Therapeutic Implications
Cancers
Carolin Czauderna, Darko Castven, Friederike L. Mahn and Jens U. Marquardt
DOI: 10.3390/cancers11081053
With contribution of the project: TP07
Transcutaneous immunization with CD40 ligation boosts cytotoxic T lymphocyte mediated antitumor immunity independent of CD4 helper cells in mice
European Journal of Immunology
Ariane Bialojan, Julian Sohl, Johanna Rausch, Pamela Aranda Lopez, Mark Denny, Peter Langguth, Ann‐Kathrin Hartmann, Hideo Yagita, Hans Christian Probst, Hansjörg Schild and Markus P. Radsak
DOI: 10.1002/eji.201848039
With contribution of the project: TP13
Myeloid cell-synthesized coagulation Factor X dampens anti-tumor immunity
Science Immunology
Claudine Graf, Petra Wilgenbus, Sven Pagel, Jennifer Pott, Federico Marini, Sabine Reyda, Maki Kitano, Stephan Macher-Göppinger, Hartmut Weiler and Wolfram Ruf
DOI: 10.1126/sciimmunol.aaw8405
With contribution of the project: TP10
PI3K inhibition reduces murine and human liver fibrogenesis in precision-cut liver slices
Biochemical Pharmacology
Emilia Gorea, Emilia Bigaeva, Anouk Oldenburger, Yong Ook Kim, Jörg F. Rippmann, Detlef Schuppan, Miriam Boersema and Peter Olinga
DOI: 10.1016/j.bcp.2019.113633
With contribution of the project: TP08
Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer
American Journal of Physiology - Gastrointestinal and Liver Physiology
Guangyan Wei, Ping An, Kahini A. Vaid, Imad Nasser, Pinzhu Huang, Li Tan, Shuangshuang Zhao, Detlef Schuppan and Yury V. Popov
DOI: 10.1152/ajpgi.00041.2019
With contribution of the project: TP08
Early Treatment of Coxsackievirus B3–Infected Animals With Soluble Coxsackievirus-Adenovirus Receptor Inhibits Development of Chronic Coxsackievirus B3 Cardiomyopathy
Circulation Heart Failure
Sandra Pinkert, Babette Dieringer, Robert Klopfleisch, Konstantinos Savvatis, Sophie Van Linthout, Markian Pryshliak, Carsten Tschöpe, Karin Klingel, Jens Kurreck, Antje Beling and Henry Fechner
DOI: 10.1161/CIRCHEARTFAILURE.119.005250
With contribution of the project: TP02
Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability
Frontiers in Oncology
Anke Werner, Daniel Pieh, Hakim Echchannaoui, Johanna Rupp, Krishnaraj Rajalingam, Matthias Theobald, Ellen I. Closs and Markus Munder
DOI: 10.3389/fonc.2019.01268
With contribution of the projects: TP05, TP06
Predisposition to Apoptosis in Hepatocellular Carcinoma: From Mechanistic Insights to Therapeutic Strategies
Frontiers in Oncology
Jens U. Marquardt and Frank Edlich
DOI: 10.3389/fonc.2019.01421
With contribution of the project: TP07
Myeloid cell–synthesized coagulation factor X dampens antitumor immunity
Science Immunology
Claudine Graf, Petra Wilgenbus, Sven Pagel, Jennifer Pott, Federico Marini, Sabine Reyda, Maki Kitano, Stephan Macher-Göppinger, Hartmut Weiler and Wolfram Ruf;
DOI:10.1126/sciimmunol.aaw8405
With contribution of the project: TP10
Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
Cell Reports
Kathrin Renner, Christina Bruss, Annette Schnell, Gudrun Koehl, Holger M. Becker, Matthias Fante, Ayse-Nur Menevse, Nathalie Kauer, Raquel Blazquez, Lisa Hacker, Sonja-Maria Decking, Toszka Bohn, Stephanie Faerber, Katja Evert, Lisa Aigle, Sabine Amslinger, Maria Landa, Oscar Krijgsman, Elisa A. Rozeman, Christina Brummer, Peter J. Siska, Katrin Singer, Stefanie Pektor, Matthias Miederer, Katrin Peter, Eva Gottfried, Wolfgang Herr, Ibtisam Marchiq, Jacques Pouyssegur, William R. Roush, SuFey Ong, Sarah Warren, Tobias Pukrop, Philipp Beckhove, Sven A. Lang, Tobias Bopp, Christian U. Blank, John L. Cleveland, Peter J. Oefner, Katja Dettmer, Mark Selby and Marina Kreutz
DOI: 10.1016/j.celrep.2019.08.068
With contribution of the project: TP01
Pan-RTK activity of soluble LRIG1 mediates AXL downregulation in glioblastoma
Neuro-Oncology Advances
Virginie Neirinckx, Ann-Christin Hau, Anne Schuster, Sabrina Fritah, Katja Tiemann, Petr V. Nazarov, André Matagne, Martyna Szpakowska, Max Meyrath, Andy Chevigné, Mirko HH Schmidt, Simone P. Niclou
DOI: 10.1093/noajnl/vdz024
With contribution of the project: TP09
The role of SVZ stem cells in glioblastoma
Cancers
Christina Altmann, Stefanie Keller & Mirko HH Schmidt
DOI: 10.3390/cancers11040448
With contribution of the project: TP09
RAF kinases are stabilized and required for dendritic cell differentiation and function
Cell Death & Differentiation
Kristina Riegel, Janine Schlöder, Marco Sobczak, Helmut Jonuleit, Bernd Thiede, Hansjörg Schild & Krishnaraj Rajalingam
DOI: 10.1038/s41418-019-0416-4
With contribution of the projects: TP05, TP13
Trends and challenges in tumor anti-angiogenic therapies
Cells
József Jászai, Mirko HH Schmidt
DOI: 10.3390/cells8091102
With contribution of the project: TP09
Humanized mice in cutaneous leishmaniasis-Suitability analysis of human PBMC transfer into immunodeficient mice
Experimental Dermatology
Michael R Fischer, Anja I Schermann, Trix Twelkmeyer, Beate Lorenz, Joanna Wegner, Helmut Jonuleit, Esther von Stebut
DOI: 10.1111/exd.13999
With contribution of the project: TP15
IL-17A/F in Leishmania major-resistant C57BL/6 mice
Experimental Dermatology
Kirsten Dietze‐Schwonberg, Susanna Lopez Kostka, Beate Lorenz, Tommy Regen, Ari Waisman, Esther von Stebut
DOI: 10.1111/exd.13896
With contribution of the project: TP15
Langerin+CD8+ dendritic cells in the splenic marginal zone: not so marginal after all.
Frontiers in Immunology
Ronald A Backer, Nathalie Diener, Björn E Clausen
DOI: 10.3389/fimmu.2019.00741
With contribution of the project: TP14
Adverse immunological imprinting by cytomegalovirus sensitizing for allergic airway disease
Medical Microbiology and Immunology
Matthias J Reddehase
DOI: 10.1007/s00430-019-00610-z.
With contribution of the project: TP11
Pediatric roots of cytomegalovirus recurrence and memory inflation in the elderly
Medical Microbiology and Immunology
Stuart P Adler, Matthias J Reddehase
DOI: 10.1007/s00430-019-00609-6
With contribution of the project: TP11
Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' résumé
Medical Microbiology and Immunology
Astrid Krmpotić A, Jürgen Podlech, Matthias J Reddehase, William J Britt, Stipan Jonjić
DOI: 10.1007/s00430-019-00600-1
With contribution of the project: TP11
Cellular reservoirs of latent cytomegaloviruses
Medical Microbiology and Immunology
Matthias J Reddehase, Niels A Lemmermann
DOI: 10.1007/s00430-019-00592-y.
With contribution of the project: TP11
Inflammation and cancer: triggers, mechanisms, and consequences
Immunity
Florian R Greten, Sergei I Grivennikov
DOI: 10.1016/j.immuni.2019.06.025
With contribution of the project: TP16
Modulating inflammation for cancer therapy
Journal of Experimental Medicine
Birgit Ritter, Florian R Greten
DOI: 10.1084/jem.20181739
With contribution of the project: TP16
Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis
Oncogene
Tiago De Oliveira, Mallika Ramakrishnan, Michaela A. Diamanti, Paul K. Ziegler, Frank Brombacher, Florian R. Greten
DOI: 10.1038/s41388-018-0551-2
With contribution of the project: TP16
ISG15 deficiency enhances HIV-1 infection by accumulating misfolded p53
mBio
Edmund Osei Kuffour, Renate König, Dieter Häussinger, Wolfgang A. Schulz, Carsten Münk
DOI: 10.1128/mBio.01342-19.
With contribution of the project: TP04
Intertwined: SAMHD1 cellular functions, restriction, and viral evasion strategies
Medical Microbiology and Immunology
Catharina Majer, Jan Moritz Schüssler, Renate König
DOI: 10.1007/s00430-019-00593-x
With contribution of the project: TP04
Function of the cargo sorting dileucine motif in a cytomegalovirus immune evasion protein
Medical Microbiology and Immunology
Anette Fink, Snježana Mikuličić, Franziska Blaum, Mathias J Reddehase, Luise Florin, Niels A Lemmermann
DOI: 10.1007/s00430-019-00604-x
With contribution of the project: TP11
A potent tumor-reactive p53-specific single-chain TCR without on- or off-target autoimmunity in vivo Molecular Therapy
Hakim Echchannaoui, Jutta Petschenka, Edite Antunes Ferreira, Beate Hauptrock Carina Lotz-Jenne, Ralf-Holger Voss, Matthias Theobald
DOI: 10.1016/j.ymthe.2018.11.00
With contribution of the project: TP06
Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells
PLoS Pathogens
Sebastian Reuter, Niels A Lemmermann, Joachim Maxeiner, Jürgen Podlech, Hendrik Beckert, Kirsten Freitag, Daniel Teschner, Frederic Ries, Christian Taube, Roland Buhl, Matthias J. Reddehase, Rafaela Holtappels
DOI: 10.1371/journal.ppat.1007595
With contribution of the projects: TP11, TP14
The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection
Markus Stempel, Baca Chan, Vanda Juranić Lisnić, Astrid Krmpotić, Josephine Hartung, Søren R Paludan, Nadia Füllbrunn, Niels A Lemmermann, Melanie M Brinkmann.
EMBO Journal
DOI: 10.15252/embj.2018100983
With contribution of the project: TP11
Transcripts expressed in cytomegalovirus latency coding for an antigenic IE/E phase peptide that drives "memory inflation"
Medical Microbiology and Immunology
Angelique Renzaho, Julia K Schmiedeke, Marion Griessl, Birgit Kühnapfel, Christof K, Niels A Lemmermann
DOI: 10.1007/s00430-019-00615-8
With contribution of the project: TP11
2018:
Tissue factor as a mediator of coagulation and signaling in cancer and chronic inflammation
Thrombosis Research
Claudine Graf and Wolfram Ruf
DOI:10.1016/j.thromres.2018.01.023
With contribution of the project: TP10
Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune
Myocarditis
Frontiers in Immunology
Ingmar Sören Meyer, Carl Christoph Goetzke, Meike Kespohl, Martina Sauter, Arnd Heuser, Volker Eckstein, Hans-Peter Vornlocher, Daniel G. Anderson, Jan Haas, Benjamin Meder, Hugo Albert Katus, Karin Klingel, Antje Beling and Florian Leuschner
DOI: 10.3389/fimmu.2018.02303
With contribution of the project: TP02
Proteasomal Protein Degradation: Adaptation of Cellular Proteolysis With Impact on Virus—and Cytokine-Mediated Damage of Heart Tissue During Myocarditis
Frontiers in Immunology
Antje Beling and Meike Kespohl
DOI: 10.3389/fimmu.2018.02620
With contribution of the project: TP02
Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
Nature Immunology
Toszka Bohn, Steffen Rapp, Natascha Luther, Matthias Klein, Till-Julius Bruehl, Nobuhiko Kojima, Pamela Aranda Lopez, Jennifer Hahlbrock, Sabine Muth, Shogo Endo, Stefanie Pektor, Almut Brand, Kathrin Renner, Vanessa Popp, Katharina Gerlach, Dennis Vogel, Christina Lueckel, Danielle Arnold-Schild, Jacques Pouyssegur, Marina Kreutz, Magdalena Huber, Jochem Koenig, Benno Weigmann, Hans-Christian Probst, Esther von Stebut, Christian Becker, Hansjoerg Schild, Edgar Schmitt, Tobias Bopp
With contribution of the projects: TP1, TP13, TP15
Fungi enter the stage of colon carcinogenesis
Immunity
Claire Conche, Florian R Greten
DOI: 10.1016/j.immuni.2018.09.002.
With contribution of the project: TP16
Mitophagy in intestinal epithelial cells triggers adaptive immunity during tumorigenesis
Cell
Paul K Ziegler, Julia Bollrath, Charles K Pallangyo, Takaji Matsutani, Özge Canli, Tiago De Oliveira, Michaela A Diamanti, Nina Müller, Jaba Gamrekelashvili, Tracy Putoczki, David Horst, Arun K Mankan, Meryem G Öner, Susanna Müller, Josef Müller-Höcker, Thomas Kirchner, Julia Slotta-Huspenina, M. Mark Taketo, Thomas Reinheckel, Stefan Dröse, Andrew C Larner, Winfried S Wels, Matthias Ernst, Tim F Greten, Melek C Arkan, Thomas Korn, Dagmar Wirth, Florian R Greten
DOI: 10.1016/j.cell.2018.05.028
With contribution of the project: TP16
USP18 (UBP43) abrogates p21-mediated inhibition of HIV-1
Journal of Virology
Edmund Osei Kuffour, Kerstin Schott, Ananda Ayyappan Jaguva Vasudevan, Jessica Holler, Wolfgang A. Schulz, Philipp A Lang, Karl S Lang, Baek Kim, Dieter Häussinger, Renate König, Carsten Münk
DOI: 10.1128/JVI.00592-18.
With contribution of the project: TP04
The Myb-related protein MYPOP is a novel intrinsic host restriction factor of oncogenic human papillomaviruses
Oncogene
Elena Wüstenhagen, Fatima Boukhallouk, Inka Negwer, Krishnaraj Rajalingam, Frank Stubenrauch, Luise Florin
DOI: 10.1038/s41388-018-0398-6
With contribution of the project: TP05
Mouse model of cytomegalovirus disease and immunotherapy in the immunocompromised host: predictions for medical translation that survived the "Test of Time"
Viruses
Matthias J Reddehase, Niels A Lemmermann
DOI: 10.3390/v10120693.
With contribution of the project: TP11
Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity
EMBO Journal
Ulrike Buehler, Katharina Schulenburg, Hajime Yurugi, Maja Šolman, Daniel Abankwa, Alexander Ulges, Stefan Tenzer, Tobias Bopp, Bernd Thiede, Frauke Zipp, Krishnaraj Rajalingam
DOI: 10.15252/embj.201899429
With contribution of the projects: TP05, TP09, TP01, Z01
EGFL7 enhances surface expression of integrin α5β1to promote angiogenesis in malignant brain tumors
EMBO Molecular Medicine
Nevenka Dudvarski Stanković, Frank Bicker, Stefanie Keller, David TW Jones, Patrick N Harter, Arne Kienzle, Clarissa Gillmann, Philipp Arnold, Anna Golebiewska, Olivier Keunen, Alf Giese, Andreas von Deimling, Tobias Bäuerle, Simone P Niclou, Michel Mittelbronn, Weilan Ye, Stefan M Pfister, Mirko HH Schmidt
DOI 10.15252/emmm.201708420
With contribution of the project: TP09
Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
Nature Communications
Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens & Renate König
DOI:10.1038/s41467-018-04671-1
With contribution of the project: TP04
Efficient delivery of human cytomegalovirus T cell antigens by attenuated Sendai virus vectors
Journal of Virology
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With contribution of the project: TP11