2021

Therapeutic Vaccination of Hematopoietic Cell Transplantation Recipients Improves Protective CD8 T-Cell Immunotherapy of Cytomegalovirus Infection

Front Immunol

Gergely KM, Podlech J, Becker S, Freitag K, Krauter S, Büscher N, Holtappels R, Plachter B, Reddehase MJ, Lemmermann NAW

10.3389/fimmu.2021.694588

Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice

Cardiovasc Res

Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A.

10.1093/cvr/cvab359

Impact of Dietary Intervention on Serum Neurofilament Light Chain in Multiple Sclerosis

Neurol Neuroimmunol Neuroinflamm

Bock M, Steffen F, Zipp F, Bittner S

10.1212/NXI.0000000000001102

Liquid biomarkers for fibrotic NASH - progress in a complex field

J Hepatol

Schuppan D, Myneni S, Surabattula R.

10.1016/j.jhep.2021.11.005

TP08

The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling

Proc Natl Acad Sci U S A

Colombo E, Horta G, Roesler MK, Ihbe N, Chhabra S, Radyushkin K, Di Liberto G, Kreutzfeldt M, Schumann S, von Engelhardt J, Merkler D, Behl C, Mittmann T, Clement AM, Waisman A, Schmeisser MJ

10.1073/pnas.2110755118

B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia

Biomedicines

Xia N, Hasselwander S, Reifenberg G, Habermeier A, Closs EI, Mimmler M, Jung R, Karbach S, Lagrange J, Wenzel P, Daiber A, Münzel T, Hövelmeyer N, Waisman A, Li H

10.3390/biomedicines9111686

TP15, TP20N

Repurposing of the ALK Inhibitor Crizotinib for Acute Leukemia and Multiple Myeloma Cells

Pharmaceuticals (Basel)

Joelle C Boulos, Mohamed E M Saeed, Manik Chatterjee, Yagmur Bülbül, Francesco Crudo, Doris Marko, Markus Munder, Sabine M Klauck, Thomas Efferth

10.3390/ph14111126

TP06

COVID-19 in multiple-myeloma patients: cellular and humoral immunity against SARS-CoV-2 in a short- and long-term view

J Mol Med (Berl)

Ivana von Metzler , Julia Campe, Sabine Huenecke, Marc S Raab, Hartmut Goldschmidt, Ralf Schubert, Holger F Rabenau, Sandra Ciesek, Hubert Serve, Evelyn Ullrich

10.1007/s00109-021-02114-x

TP05, TP12

Anticoagulation with Factor Xa Inhibitors Is Associated with Improved Overall Response and Progression-Free Survival in Patients with Metastatic Malignant Melanoma Receiving Immune Checkpoint Inhibitors—A Retrospective, Real-World Cohort Study

Cancers (Basel)

Maximilian Haist, Henner Stege, Saskia Pemler, Jaqueline Heinz, Maria Isabel Fleischer, Claudine Graf, Wolfram Ruf, Carmen Loquai, Stephan Grabbe

10.3390/cancers13205103

TP10

NFAT5 Controls the Integrity of Epidermis

Front Immunol

Khalid Muhammad, Delicia Xavier, Stefan Klein-Hessling, Muhammad Azeem, Tabea Rauschenberger, Krisna Murti, Andris Avots, Matthias Goebeler, Matthias Klein , Tobias Bopp, Malte Sielaff, Stefan Tenzer, Sigrid Möckel, José Aramburu, Cristina López-Rodríguez, Andreas Kerstan, Edgar Serfling

10.3389/fimmu.2021.780727

TP01, Z01

Cross-reactive, natural IgG recognizing L. major promote parasite internalization by dendritic cells and promote protective immunity

J Mol Med (Berl)

Dermicik F, Lopez Kostka S, Tenzer S, Waisman A, Von Stebut E

10.1007/s00109-021-02114-x

TP15, Z01

Repositioning T H cell polarization from single cytokines to complex help

Nat Immunol

Tuzlak S, Dejean AS, Iannacone M, Quintana FJ, Waisman A, Ginhoux F, Korn T, Becher B

10.1038/s41590-021-01009-w

SAMHD1 in cancer: curse or cure?

J Mol Med (Berl)

Schott K, Majer C, Bulashevska A, Childs L, Schmidt MHH, Rajalingam K, Munder, M, König R.

10.1007/s00109-021-02131-w. Epub ahead of print. PMID: 34480199.

TP04, TP05, TP06 & TP09

Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression

Nat Commun

Johann K, Bohn T, Shahneh F, Luther N, Birke A, Jaurich H, Helm M, Klein M, Raker VK, Bopp T, Barz M, Becker C

10.1038/s41467-021-26269-w

TP01

ERK5 modulates IL-6 secretion and contributes to tumor-induced immune suppression

Cell Death Dis

Riegel K, Yurugi H, Schlöder J, Jonuleit H, Kaulich M, Kirschner F, Arnold-Schild D, Tenzer S, Schild H, Rajalingam K

10.1038/s41419-021-04257-8

TP05

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

Nat Immunol

Munnur D, Teo Q, Eggermont D, Lee HHY, Thery F, Ho J, van Leur SW, Ng WWS, Siu LYL, Beling A, Ploegh H, Pinto-Fernandez A, Damianou A, Kessler B, Impens F, Mok CKP, Sanyal S.

10.21203/rs.3.rs-63942/v1

Ring Finger Protein 213 Assembles into a Sensor for ISGylated Proteins with Antimicrobial Activity

Nat Commun

Thery F, Martina L, Asselman C, Zhang Y, Vessely M, Repo H, Sedeyn K, Moschonas GD, Bredow C, Teo QW, Zhang J, Leandro K, Eggermont D, De Sutter D, Boucher K, Hochepied T, Festjens N, Callewaert N, Saelens X, Dermaut B, Knobeloch KP, Beling A, Sanyal S, Radoshevich L, Eyckerman S, Impens F

10.1101/2021.06.03.446796

Immunohistochemical markers for histopathological diagnosis and differentiation of acute cutaneous graft-versus-host disease.

Exp Dermatol

Wegner J, Weidenthaler-Barth B, Engelbert J, Knothe M, Braun C, Helbig D, Sacher C, Kreft A, Wagner EM, Ziemer M, Meyer RG, von Stebut E.

10.1111/exd.14416

CD27 expression on Treg cells limits immune responses against tumors.

J Mol Med (Berl).

Muth S, Klaric A, Radsak M, Schild H, Probst HC

10.1007/s00109-021-02116-9

TP13

Unleashing the power of NK cells in anticancer immunotherapy.

J Mol Med (Berl).

Vogler M, Shanmugalingam S, Särchen V, Reindl LM, Grèze V, Buchinger L, Kühn M, Ullrich E.

10.1007/s00109-021-02120-z

TP12

Immunodominant Cytomegalovirus Epitopes Suppress Subdominant Epitopes in the Generation of High-Avidity CD8 T Cells.

Pathogens.

Freitag K, Hamdan S, Reddehase MJ, Holtappels R.

10.3390/pathogens10080956.

TP11, TP14

Direct Evidence for Viral Antigen Presentation during Latent Cytomegalovirus Infection.

Pathogens

Lemmermann NAW, Reddehase MJ

10.3390/pathogens10060731

Consequence of Histoincompatibility beyond GvH-Reaction in Cytomegalovirus Disease Associated with Allogeneic Hematopoietic Cell Transplantation: Change of Paradigm.

Viruses.

Reddehase MJ, Holtappels R, Lemmermann NAW.

10.3390/v13081530

TP11, TP14

Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation.

Proc Natl Acad Sci U S A.

Larochelle C, Wasser B, Jamann H, Löffel JT, Cui QL, Tastet O, Schillner M, Luchtman D, Birkenstock J, Stroh A, Antel J, Bittner S, Zipp F.

10.1073/pnas.2025813118

The neuroinflammation collection: a vision for expanding neuro-immune crosstalk in Brain.

Brain.

Irani SR, Nath A, Zipp F.

10.1093/brain/awab187

TNF-α blockade may lead to improvement of vascular function in psoriasis patients.

Exp Dermatol.

Wegner J, Karbach S, Drosos I, Schnorbus B, Muxel S, Schmidt F, Wenzel P, Waisman A, Münzel T, Gori T, von Stebut E.

10.1111/exd.14452

Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity.

J Immunother Cancer.

Legscha KJ, Antunes Ferreira E, Chamoun A, Lang A, Awwad MHS, Ton GNHQ, Galetzka D, Guezguez B, Hundemer M, Bourdon JC, Munder M, Theobald M, Echchannaoui H.

10.1136/jitc-2020-001846

TP06

Targeting Immune Modulators in Glioma While Avoiding Autoimmune Conditions.

Cancers (Basel).

Bitar L, Schumann U, König R, Zipp F, Schmidt MHH.

10.3390/cancers13143524

TP04, TP09

Pathogenic lipid-binding antiphospholipid antibodies are associated with severity of COVID-19.

J Thromb Haemost.

Hollerbach A, Müller-Calleja N, Pedrosa D, Canisius A, Sprinzl MF, Falter T, Rossmann H, Bodenstein M, Werner C, Sagoschen I, Münzel T, Schreiner O, Sivanathan V, Reuter M, Niermann J, Galle PR, Teyton L, Ruf W, Lackner KJ.

10.1111/jth.15455

TP02, TP08, TP10

Advocacy of targeting protease-activated receptors in severe coronavirus disease 2019.

Br J Pharmacol.

Subramaniam S, Ruf W, Bosmann M

10.1111/bph.15587

TP02, TP10

Exploration of Analgesia with Tramadol in the Coxsackievirus B3 Myocarditis Mouse Model

Viruses

Pinkert S, Kespohl M, Kelm N, Kaya Z, Heuser A, Klingel K, Beling A

10.3390/v13071222

Coxsackievirus B3 Exploits the Ubiquitin-Proteasome System to Facilitate Viral Replication.

Viruses

Voss M, Braun V, Bredow C, Kloetzel PM, Beling A.

10.3390/v13071360

Microbial short-chain fatty acids modulate CD8⁺ T cell responses and improve adoptive immunotherapy for cancer.

Nat Commun.

Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, Klein M, Wempe A, Leister H, Raifer H, Picard F, Muhammad K, Ohl K, Romero R, Fischer F, Bauer CA, Huber M, Gress TM, Lauth M, Danhof S, Bopp T, Nerreter T, Mulder IE, Steinhoff U, Hudecek M, Visekruna A.

10.1038/s41467-021-24331-1. PMID: 34210970; PMCID: PMC8249424.

TP01

Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.

JCI Insight

Czauderna C, Poplawski A, O Rourke CJ, Castven D, Pérez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder DA, Schindeldecker M, Straub BK, Galle PR, Andersen JB, Thorgeirsson SS, Park YN, Marquardt JU.

10.1172/jci.insight.146196.

TP07

Depletion of CD56+CD3+ invariant natural killer T cells prevents allergen-induced inflammation in humanized mice

J Allergy Clin Immunol

Ose R, Weigmann B, Schuppan D, Waisman A, Saloga J, Bellinghausen I

10.1016/j.jaci.2021.05.005

Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany

Gene Ther

Albinger N, Hartmann J, Ullrich E

10.1038/s41434-021-00246-w

TP12

The neuroinflammation collection: a vision for expanding neuro-immune crosstalk in Brain

Brain

Irani SR, Nath A, Zipp F

10.1093/brain/awab187

Characterization and Manipulation of the Crosstalk Between Dendritic and Natural Killer Cells Within the Tumor Microenvironment

Front Immunol

Jacobs B, Gebel V, Heger L, Grèze V, Schild H, Dudziak D, Ullrich E

10.3389/fimmu.2021.670540

TP12, TP13

OpenTIMS, TimsPy, and TimsR: Open and Easy Access to timsTOF Raw Data

J Proteome Res

Łącki MK, Startek MP, Brehmer S, Distler U, Tenzer S

10.1021/acs.jproteome.0c00962

TPZ01

Stochastic Episodes of Latent Cytomegalovirus Transcription Drive CD8 T-Cell "Memory Inflation" and Avoid Immune Evasion

Front Immunol

Griessl M, Renzaho A, Freitag K, Seckert CK, Reddehase MJ, Lemmermann NAW

10.3389/fimmu.2021.668885

The Consumption of Cholesterol-Enriched Diets Conditions the Development of a Subtype of HCC with High Aggressiveness and Poor Prognosis

Cancers (Basel)

Simoni-Nieves A, Salas-Silva S, Chávez-Rodríguez L, Escobedo-Calvario A, Desoteux M, Bucio L, Souza V, Miranda-Labra RU, Muñoz-Espinosa LE, Coulouarn C, Gutiérrez-Ruiz MC, Marquardt JU, Gomez-Quiroz LE

10.3390/cancers13071721

TP07

Revisiting Current Concepts on the Tolerogenicity of Steady-State Dendritic Cell Subsets and Their Maturation Stages

Lutz MB, Backer RA, Clausen BE

DOI: 10.4049/jimmunol.2001315

TP14

Arming Immune Cells for Battle: A Brief Journey through the Advancements of T and NK Cell Immunotherapy

Philipp Wendel, Lisa Marie Reindl, Tobias Bexte, Leander Künnemeyer, Vinzenz Särchen, Nawid Albinger, Andreas Meckensen, Eva Rettinger, Tobias Bopp, Evelyn Ullrich

Cancers

DOI: 10.3390/cancers13061481

TP01, TP12

Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany

Nawid Albinger, Jessica Hartmann, Evelyn Ullrich

Gene Therapy

DOI: 10.1038/s41434-021-00246-w

TP12

Motor ability, physical self-concept and health-related quality of life in pediatric cancer survivors

Cancer Med

Benzing V, Siegwart V, Spitzhüttl J, Schmid J, Grotzer M, Roebers CM, Steinlin M, Leibundgut K, Everts R, Schmidt M

10.1002/cam4.3750

New 3-Aryl-2-(2-thienyl)acrylonitriles with High Activity Against Hepatoma Cells

Int J Mol Sci

Schaller E, Ma A, Gosch LC, Klefenz A, Schaller D, Goehringer N, Kaps L, Schuppan D, Volkamer A, Schobert R, Biersack B, Nitzsche B, Höpfner M

10.3390/ijms22052243

TP08

Selective elimination of immunosuppressive T cells in patients with multiple myeloma

Leukemia

Awwad MHS, Mahmoud A, Bruns H, Echchannaoui H, Kriegsmann K, Lutz R, Raab MS, Bertsch U, Munder M, Jauch A, Weisel K, Maier B, Weinhold N, Salwender HJ, Eckstein V, Hänel M, Fenk R, Dürig J, Brors B, Benner A, Müller-Tidow C, Goldschmidt H, Hundemer M

DOI: 10.1038/s41375-021-01172-x

TP06

Druggable genome and precision medicine in cancer: current challenges

FEBS J

Dupont CA, Riegel K, Pompaiah M, Juhl H, Rajalingam K

DOI: 10.1111/febs.15788

TP05

Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection

Basic Res Cardiol

Goetzke CC, Althof N, Neumaier HL, Heuser A, Kaya Z, Kespohl M, Klingel K, Beling A

DOI: 10.1007/s00395-021-00848-w