SAMHD1: Impact on inflammation and DNA damage response in HIV-1 and malignant diseases
Abstract:
SAMHD1, a negative regulator of the innate response, is a mediator of immune evasion for HIV-1 and has been linked DNA damage response and malignant tumor development if mutated or downregulated. A key to understand the role of SAMHD1 in immune escape mechanisms of chronic viral infections and cancer will be to characterize (i) identified proteins that may control the activity of SAMHD1 and (ii) the microenvironment induced by inactive SAMHD1. These results will support the development of compounds to improve vaccine design aiming to induce specific immune responses and to support novel strategies to fight cancer.
Principal investigator:
Dr. phil. nat. Renate König
Forschungsgruppe „Pathogen-Wirt Interaktionen“
Paul-Ehrlich-Institut
Paul-Ehrlich-Straße 51-59, 63225 Langen
Phone: +49 (0)6103 774019
E-mail: renate.koenig@pei.de
Web: https://www.pei.de/SharedDocs/Personen/DE/mitarbeiter/g-k/koenig-renate-en.html
Postdocs:
Dr. Kerstin Schott
Dr. Nina Hein-Fuchs
Dr. Lise Lauterbach-Rivière
Doctoral candidate:
Catharina Majer
Project-related publications:
Schott S, Riess M & König R (2017): Role of Innate Genes in HIV Replication. In Curr Top Microbiol Immunol Compans RW, Honjo T, Malissen B, Aktories K, Rappuoli R, Galan JE, Ahmed R, Palme K, Casadevall A, Garcia-Sastre A (ed) pp1-43. Springer
Riess M, Fuchs NV, Idica A, Hamdorf M, Flory E, Pedersen IM & König R (2017) Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a. J Biol Chem 292: 264–277
Sommer AFR, Riviere L, Qu B, Schott K, Riess M, Ni Y, Shepard C, Schnellbacher E, Finkernagel M, Himmelsbach K, Welzel K, Kettern N, Donnerhak C, Munk C, Flory E, Liese J, Kim B, Urban S & Konig R (2016) Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle. Sci Rep 6: 26616
Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LCF, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, Gonzalez MG, Nguyen Q, Brass A, Elledge S, White M Shapira S, Hacohen N, Karlas A, Meyer TF, Shales M, Gatorano A, Johnson JR, Jang G, Johnson T, Verschueren E, Sanders D, Krogan N, Shaw M, König R*, Stertz S*, Garcia-Sastre* & Chanda SK* (2015) Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. Cell Host Microbe 18: 723–735 (*joint corresponding authors)
Berger A, Sommer, Andreas F R, Zwarg J, Hamdorf M, Welzel K, Esly N, Panitz S, Reuter A, Ramos I, Jatiani A, Mulder, Lubbertus C F, Fernandez-Sesma A, Rutsch F, Simon V, König R* & Flory E* (2011) SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection. PLoS Pathog 7: e1002425