2024

Blocking interleukin-1 receptor type 1 (IL-1R1) signaling in hepatocytes slows down diethylnitrosamine-induced liver tumor growth in obese mice

Hepatol Commun.

Gehrke N, Hofmann LJ, Straub BK, Ridder DA, Waisman A, Kaps L, Galle PR, Schattenberg JM


Multiparameter Flow Cytometric Analysis of the Conventional and Monocyte-Derived DC Compartment in the Murine Spleen

Vaccines (Basel)

Backer RA, Probst HC, Clausen BE


Recurrent late-onset neutropenia following treatment with different B cell-depleting strategies in multiple sclerosis

Med.

Protopapa M, Schraad M, Pape K, Steffen F, Steenken L, Zipp F, Fleischer V, Bittner S.


EGFL7: An emerging biomarker with great therapeutic potential.

Pharmacol Ther

Fabian C, Mahajan S, Schmidt MHH


Serum protein risk stratification score for diagnostic evaluation of metabolic dysfunction-associated steatohepatitis

Hepatol Commun.

Lai M, Dillon ST, Gu X, Morhardt TL, Xu Y, Chan NY, Xiong B, Can H, Ngo LH, Jin L, Zhang X, Moreira CC, Leite NC, Villela-Nogueira CA, Otu HH, Schattenberg JM, Schuppan D, Afdhal NH, Libermann TA


Integrate and Conquer: pan-cancer proteogenomics uncovers cancer vulnerabilities and therapeutic opportunities

Signal Transduct Target Ther

Chakraborty D, Romero R, Rajalingam K.


The evolutionary tug-of-war of macrophage metabolism during bacterial infection

Trends Endocrinol Metab.

Almeida L, Dhillon-LaBrooy A, Sparwasser T


Embryo-restricted responses to maternal IL-17A promote neurodevelopmental disorders in mouse offspring.

Mol Psychiatry

Andruszewski D, Uhlfelder DC, Desiato G, Regen T, Schelmbauer C, Blanfeld M, Scherer L, Radyushkin K, Pozzi D, Waisman A, Mufazalov IA.


Manufacturing of primary CAr-NK cells in an automated system for the treatment of acute myeloid leukemia

Bone Marrow Transplant.

Albinger N, Müller S, Kostyra J, Kuska J, Mertlitz S, Penack O, Zhang C, Möker N, Ullrich E


Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation

Eur Heart J open

Knopp T, Jung R, Wild J, Bochenek ML, Efentakis P, Lehmann A, Bieler T, Garlapati V, Richter C, Molitor M, Perius K, Finger S, Lagrange J, Ghasemi I, Zifkos K, Kommoss KS, Masri J, Reißig S, Randriamboavonjy V, Wunderlich T, Hövelmeyer N, Weber ANR, Mufazalov IA, Bosmann M, Bechmann I, Fleming I, Oelze M, Daiber A, Münzel T, Schäfer K, Wenzel P, Waisman A, Karbach S 10.1093/ehjopen/oeae046


Dual fluorescence reporter mice for Ccl3 transcription, translation, and intercellular communication 

J Exp Med 

Rodrigo MB, De Min A, Jorch SK, Martin-Higueras C, Baumgart AK, Goldyn B, Becker S, Garbi N, Lemmermann NA, Kurts C 

10.1084/jem.20231814

TP11


The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells 

Gut 

López-Gil JC, García-Silva S, Ruiz-Cañas L, Navarro D, Palencia-Campos A, Giráldez-Trujillo A, Earl J, Dorado J, Gómez-López G, Monfort-Vengut A, Alcalá S, Gaida MM, García-Mulero S, Cabezas-Sáinz P, Batres-Ramos S, Barreto E, Sánchez-Tomero P, Vallespinós M, Ambler L, Lin ML, Aicher A, García García de Paredes A, de la Pinta C, Sanjuanbenito A, Ruz-Caracuel I, Rodríguez-Garrote M, Guerra C, Carrato A, de Cárcer G, Sánchez L, Nombela-Arrieta C, Espinet E, Sanchez-Arevalo Lobo VJ, Heeschen C, Sainz B Jr 

10.1136/gutjnl-2023-330995 

TPQ1, TP22


The atypical IκB family member Bcl3 determines differentiation and fate of intestinal RORγt+ regulatory T-cell subsets 

Mucosal Immunology 

Köhler A, Geiselhöringer AL, Kolland D, Kreft L, Wichmann N, Hils M, Pasztoi M, Zurkowski E, Vogt J, Kübelbeck T, Biedermann T, Schmitz I, Hansen W, Kramer D, Gaida MM, Schmidt-Weber CB, Hoevelmeyer N, Ohnmacht C 

10.1016/j.mucimm.2024.04.002 

TP20


RNA-encoded Interleukin 2 with Extended Bioavailability Amplifies RNA Vaccine-Induced Antitumor T-cell Immunity 

Cancer Immunol Res 

Peters D, Kranz LM, Eisel D, Diken M, Kreiter S, Türeci Ö, Sahin U, Vormehr M 

10.1158/2326-6066.CIR-23-0701 

TP22N


TNFR1 signaling promotes pancreatic tumor growth by limiting dendritic cell number and function 

Cell Rep Med 

Alam MS, Gaida MM, Witzel HR, Otsuka S, Abbasi A, Guerin T, Abdelmaksoud A, Wong N, Cam MC, Kozlov S, Ashwell JD 

10.1016/j.xcrm.2024.101696 

TPQ1, TP22N


Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells 

Mol Oncol 

Kansy AG, Ashry R, Mustafa AM, Alfayomy AM, Radsak MP, Zeyn Y, Bros M, Sippl W, Krämer OH 

10.1002/1878-0261.13638 

TP21N


GSK-3ß in Dendritic Cells Exerts Opposite Functions in Regulating Cross-Priming and Memory  CD8 T Cell Responses Independent of ß-Catenin 

Vaccines (Basel) 

Fu C, Wang J, Ma T, Yin C, Zhou L, Clausen BE, Mi QS, Jiang A 

10.3390/vaccines12091037 

TP20N


ß-Catenin in Dendritic Cells Negatively Regulates CD8 T Cell Immune Responses through the Immune Checkpoint Molecule Tim-3 

Vaccines (Basel) 

Fu C, Wang J, Ma T, Yin C, Zhou L, Clausen BE, Mi QS, Jiang A 

10.3390/vaccines12050460 

TP20N


Isolation and high-dimensional flow cytometric analysis of tumor-infiltrating leukocytes in a mouse model of colorectal cancer 

Front Immunol 

Eich C, Vogt JF, Längst V, Clausen BE, Hövelmeyer N 

10.3389/fimmu.2024.1295863

TP20N


Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation 

J Mol Med (Berl) 

Schramm E, Becker V, Palagi I, Müller M, Rösler T, Durak F, Ebering A, Karram K, von Stebut E, Schmeisser MJ, Waisman A 

10.1007/s00109-024-02489-7 

TP15


Natural antibodies are required for clearance of necrotic cells and recovery from acute liver injury 

JHEP Rep 

Mattos MS, Vandendriessche S, Schuermans S, Feyaerts L, Hövelmeyer N, Waisman A, Marques PE 

10.1016/j.jhepr.2024.101013 

TP15, TP20N


A Th17 cell-instrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation 

Cell Metab 

Bonetti L, Horkova V, Grusdat M, Longworth J, Guerra L, Kurniawan H, Franchina DG, Soriano-Baguet L, Binsfeld C, Verschueren C, Spath S, Ewen A, Koncina E, Gérardy JJ, Kobayashi T, Dostert C, Farinelle S, Härm J, Fan YT, Chen Y, Harris IS, Lang PA, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D 

10.1016/j.cmet.2024.06.010 

TP15


Atypical MAPKs in cancer 

FEBS J 

Dahm K, Vijayarangakannan P, Wollscheid HP, Schild H, Rajalingam K 

10.1111/febs.17283 

TP05, TP13


CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells 

Nat Commun 

Bexte T, Albinger N, Al Ajami A, Wendel P, Buchinger L, Gessner A, Alzubi J, Särchen V, Vogler M, Rasheed HM, Jung BA, Wolf S, Bhayadia R, Oellerich T, Klusmann JH, Penack O, Möker N, Cathomen T, Rieger MA, Imkeller K, Ullrich E 

10.1038/s41467-024-52388-1 

TP12


Immune profiling and functional analysis of NK and T cells in ataxia telangiectasia 

Front Immunol 

Graafen L, Heinze A, Albinger N, Salzmann-Manrique E, Ganß F, Hünecke S, Cappel C, Wölke S, Donath H, Trischler J, Theilen TM, Heller C, Königs C, Ehl S, Bader P, Klingebiel T, Klusmann JH, Zielen S, Schubert R, Ullrich E 

10.3389/fimmu.2024.1377955 

TP12


CD16+ as predictive marker for early relapse in aggressive B-NHL/DLBCL patients 

Mol Cancer

Zöphel S, Küchler N, Jansky J, Hoxha C, Schäfer G, Weise JJ, Vialle J, Kaschek L, Stopper G, Eichler H, Yildiz D, Moter A, Wendel P, Ullrich E, Schormann C, Rixecker T, Cetin O, Neumann F, Orth P, Bewarder M, Hoth M, Thurner L, Schwarz EC 

10.1186/s12943-024-02123-7 

TP12


Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors 

Mol Ther Bexte T, Botezatu L, Miskey C, Gierschek F, Moter A, Wendel P, Reindl LM, Campe J, Villena-Ossa JF, Gebel V, Stein K, Cathomen T, Cremer A, Wels WS, Hudecek M, Ivics Z, Ullrich E 

10.1016/j.ymthe.2024.05.022 

TP12


Thunder-DDA-PASEF enables high-coverage immunopeptidomics and is boosted by MS2Rescore with MS2PIP timsTOF fragmentation prediction model 

Nat Commun Gomez-Zepeda D, Arnold-Schild D, Beyrle J, Declercq A, Gabriels R, Kumm E, Preikschat A, Łącki MK, Hirschler A, Rijal JB, Carapito C, Martens L, Distler U, Schild H, Tenzer S 

10.1038/s41467-024-46380-y 

TP13, Q01


Cytomegalovirus inhihbitors of programmed cell death restrict antigen cross-presentation in the priming of antiviral CD8 T cells 

PLoS Pathog Ebert S, Böhm V, Büttner JK, Brune W, Brinkmann MM, Holtappels R, Reddehase MJ, Lemmermann NAW 

10.1371/journal.ppat.1012173 

TP11


The effector program of human CD8 T cells supports tissue remodeling 

J Exp Med Delacher M, Schmidleithner L, Simon M, Stüve P, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Ruhland B, Hofmann V, Bittner S, Ritter U, Pant A, Helbich SS, Voss M, Lemmermann NA, Bessiri-Schake L, Bohn T, Eigenberger A, Menevse AN, Gebhard C, Strieder N, Abken H, Rehli M, Huehn J, Beckhove P, Hehlgans T, Junger H, Geissler EK, Prantl L, Werner JM, Schmidl C, Brors B, Imbusch CD, Feuerer M 

10.1084/jem.20230488 

TP19N


Microglia in retinal angiogenesis and diabetic retinopathy 

Angiogenesis 

Hu A, Schmidt MHH, Heinig N 

10.1007/s10456-024-09911-1 

TP09


The fibroblast hormone Endotrophin is a biomarker of mortality in chronic diseases  

Matrix Biol 

Genovese F, Bager C, Frederiksen P, Vazquez D, Sand JMB, Jenkins RG, Maher TM, Stewart ID, Molyneaux PL, Fahy WA, Wain LV, Vestbo J, Nanthakumar C, Shaker SB, Hoyer N, Leeming DJ, George J, Trebicka J, Rasmussen DGK, Hansen MK, Cockwell P, Kremer D, Bakker SJ, Selby NM, Reese-Petersen AL, González A, Núñez J, Rossing P, Nissen NI, Boisen MK, Chen IM, Zhao L, Karsdal MA, Schuppan D 

10.1016/j.matbio.2024.06.003 

TP08


Acetylation of SAMHD11 at lysine 580 is crucial for blocking HIV-1 infection 

mBio Bulnes-Ramos A, Schott K, Rabinowitz J, Luchsinger C, Bertelli C, Miyagi E, Yu CH, Persaud M, Shepard C, König R, Kim B, Ivanov DN, Strebel K, Diaz-Griffero F 

10.1128/mbio.01958-24 

TP04


Artificial intelligence and neoantigens: paving the path for precision cancer immunotherapy 

Front Immunol 

Bulashevska A, Nacsa Z, Lang F, Braun M, Machyna M, Diken M, Childs L, König R 

10.3389/fimmu.2024.1394003

TP04


The ISG15 Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication 

Viruses 

Lin C, Kuffour EO, Li T, Gertzen CGW, Kaiser J, Luedde T, König R, Gohlke H, Münk C 

10.3390/v16040485 

TP04


Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2 

Gut Microbes Rondeau 

LE, Da Luz BB, Santiago A, Bermudez-Brito M, Hann A, De Palma G, Jury J, Wang X, Verdu EF, Galipeau HJ, Rolland C, Deraison C, Ruf W, Bercik P, Vergnolle N, Caminero A 

10.1080/19490976.2024.2387857 

TP02


Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer 

Cancer cell 

Calì B, Troiani M, Bressan S, Attanasio G, Merler S, Moscarda V, Mosole S, Ricci E, Guo C, Yuan W, Gallagher L, Lundberg A, Bernett I, Figueiredo I, Arzola RA, Abreut EB, D'Ambrosio M, Bancaro N, Brina D, Zumerle S, Pasquini E, Maddalena M, Lai P, Colucci M, Pernigoni N, Rinaldi A, Minardi D, Morlacco A, Moro FD, Sabbadin M, Galuppini F, Fassan M, Rüschoff JH, Moch H, Rescigno P, Francini E, Saieva C, Modesti M, Theurillat JP, Gillessen S, Wilgenbus P, Graf C, Ruf W, de Bono J, Alimonti A 

10.1016/j.ccell.2024.08.018 

TP10


Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination 

Front Immunol 

Heine A, Lemmermann NAW, Flores C, Becker-Gotot J, Garbi N, Brossart P, Kurts C 

10.3389/fimmu.2024.1338499 

TP11


Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution after hematopoietic cell transplantation

Front Immunol 

Holtappels R, Büttner JK, Freitag K, Reddehase MJ, Lemmermann NA 

10.3389/fimmu.2024.1355153 

TP11


Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells

Clin Transl Med  

Neuhaus F, Lieber S, Shinkevich V, Steitz AM, Raifer H, Roth K, Finkernagel F, Worzfeld T, Burchert A, Keber C, Nist A, Stiewe T, Reinartz S, Beutgen VM, Graumann J, Pauck K, Garn H, Gaida M, Müller R, Huber M 

10.1002/ctm2.1604 

TP22, TPQ1


Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients 

Leukemia 

Enssle JC, Campe J, Moter A, Voit I, Gessner A, Yu W, Wolf S, Steffen B, Serve H, Bremm M, Huenecke S, Lohoff M, Vehreschild M, Rabenau HF, Widera M, Ciesek S, Oellerich T, Imkeller K, Rieger MA, von Metzler I, Ullrich E 

10.1038/s41375-023-02070-0 

TP5, TP12


Nucleic acid sensing promotes inflammatory monocyte migration through biased coagulation factor VIIa signaling 

Blood

Zelaya H, Grunz K, Nguyen TS, Habibi A, Witzler C, Reyda S, Gonzalez-Menendez I, Quintanilla-Martinez L, Bosmann M, Weiler H, Ruf W 

10.1182/blood.2023021149 

TP02, TP10


Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development 

Blood 

Müller-Calleja N, Grunz K, Nguyen TS, Posma J, Pedrosa D, Meineck M, Hollerbach A, Braun J, Muth S, Schild H, Saar K, Hübner N, Krishnaswamy S, Royce J, Teyton L, Lemmermann N, Weinmann-Menke J, Lackner KJ, Ruf W 

10.1182/blood.2023022276 

TP02, TP11, TP13, TP21N


Immune damage in Long Covid 

Science 

Ruf W 

10.1126/science.adn1077 

TP02


TF-FVIIa PAR2-β-Arrestin Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection of Mice 

Arterioscler Thromb Vasc Biol 

Kespohl M, Goetzke CC, Althof N, Bredow C, Kelm N, Pinkert S, Bukur T, Bukur V, Grunz K, Kaur D, Heuser A, Mülleder M, Sauter M, Klingel K, Weiler H, Berndt N, Gaida MM, Ruf W, Beling A 

10.1161/ATVBAHA.123.320157 

TP02, TP22N


ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection 

Cardiovasc Res 

Bredow C, Thery F, Wirth EK, Ochs S, Kespohl M, Kleinau G, Kelm N, Gimber N, Schmoranzer J, Voss M, Klingel K, Spranger J, Renko K, Ralser M, Mülleder M, Heuser A, Knobeloch KP, Scheerer P, Kirwan J, Brüning U, Berndt N, Impens F, Beling A 

10.1093/cvr/cvae026

TP02