2023

AKT activity orchestrates marginal zone B cell development in mice and humans

Cell Rep

Cox EM, El-Behi M, Ries S, Vogt JF, Kohlhaas V, Michna T, Manfroi B, Al-Maarri M, Wanke F, Tirosh B, Pondarre C, Lezeau H, Yogev N, Mittenzwei R, Descatoire M, Weller S, Weill JC, Reynaud CA, Boudinot P, Jouneau L, Tenzer S, Distler U, Rensing-Ehl A, König C, Staniek J, Rizzi M, Magérus A, Rieux-Laucat F, Wunderlich FT, Hövelmeyer N, Fillatreau S

10.1016/j.celrep.2023.112378

Mit Beteiligung von: TP20

Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis

Oncoimmunology

Frueh JT, Campe J, Sunaga-Franze DY, Verheyden NA, Ghimire S, Meedt E, Haslinger D, Harenkamp S, Staudenraus D, Sauer S, Kreft A, Schubert R, Lohoff M, Krueger A, Bonig H, Chiocchetti AG, Zeiser R, Holler E, Ullrich E

10.1080/2162402X.2023.2296712

Mit Beteiligung von: TP12

Editorial for "Impact of Regorafenib on Endothelial Transdifferentiation of Glioblastoma Stem-like cells"

Cancers (Basel)

Kolothara Unnikrishnan M, Schmidt MHH

10.3390/cancers15153830

Mit Beteiligung von: TP09

Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues

Eur J Immunol.

Probst HC, Stoitzner P, Amon L, Backer RA, Brand A, Chen J, Clausen BE, Dieckmann S, Dudziak D, Heger L, Hodapp K, Hornsteiner F, Hovav AH, Jacobi L, Ji X, Kamenjarin N, Lahl K, Lahmar I, Lakus J, Lehmann CHK, Ortner D, Picard M, Roberti MP, Rossnagel L, Saba Y, Schalla C, Schlitzer A, Schraml BU, Schütze K, Seichter A, Seré K, Seretis A, Sopper S, Strandt H, Sykora MM, Theobald H, Tripp CH, Zitvogel L

10.1002/eji.202249819

Mit Beteiligung von: TP13, TP20N

Guidelines for DC preparation and flow cytometry analysis of mouse lymphohematopoietic tissues

Eur J Immunol.

Amon L, Dudziak D, Backer RA, Clausen BE, Gmeiner C, Heger L, Jacobi L, Lehmann CHK, Probst HC, Seichter A, Tchitashvili G, Tochoedo NR, Trapaidze L, Vurnek D

10.1002/eji.202249893

Mit der Beteiligung von: TP13, TP20N

Guidelines for mouse and human DC functional assays

Eur J Immunol.

Clausen BE, Amon L, Backer RA, Berod L, Bopp T, Brand A, Burgdorf S, Chen L, Da M, Distler U, Dress RJ, Dudziak D, Dutertre CA, Eich C, Gabele A, Geiger M, Ginhoux F, Giusiano L, Godoy GJ, Hamouda AEI, Hatscher L, Heger L, Heidkamp GF, Hernandez LC, Jacobi L, Kaszubowski T, Kong WT, Lehmann CHK, López-López T, Mahnke K, Nitsche D, Renkawitz J, Reza RA, Sáez PJ, Schlautmann L, Schmitt MT, Seichter A, Sielaff M, Sparwasser T, Stoitzner P, Tchitashvili G, Tenzer S, Tochoedo NR, Vurnek D, Zink F, Hieronymus T

10.1002/eji.202249925

Mit der Beteiligung von: TP01, TP11, TP18, TP20N, TPZ01

Direct antigen presentation is the canonical pathway of cytomegalovirus CD8 T-cell priming regulated by balanced immune evasion ensuring a strong antiviral response 

Front Immunol

Büttner JK, Becker S, Fink A, Brinkmann MM, Holtappels R, Reddehase MJ, Lemmermann NA

10.3389/fimmu.2023.1272166

TP11

Characterization of BV6-Induced Sensitization to the NK Cell Killing of Pediatric Rhabdomyosarcoma Spheroids

Cells

Särchen V, Reindl LM, Wiedemann S, Shanmugalingam S, Bukur T, Becker J, Suchan M, Ullrich E, Vogler M

10.3390/cells12060906

TP12, TPQ01

Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells

PLoS Pathog

Holtappels R, Becker S, Hamdan S, Freitag K, Podlech J, Lemmermann NA, Reddehase MJ

10.1371/journal.ppat.1011643

TP11

IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts

Gut

Picard FSR, Lutz V, Brichkina A, Neuhaus F, Ruckenbrod T, Hupfer A, Raifer H, Klein M, Bopp T, Pfefferle PI, Savai R, Prinz I, Waisman A, Moos S, Chang HD, Heinrich S, Bartsch DK, Buchholz M, Singh S, Tu M, Klein L, Bauer C, Liefke R, Burchert A, Chung HR, Mayer P, Gress TM, Lauth M, Gaida M, Huber M

10.1136/gutjnl-2022-327855

TP01, TP15, TP22, TPQ1

Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis

Clin Transl Med

Kriegsmann M, Kriegsmann K, Steinbuss G, Zgorzelski C, Albrecht T, Heinrich S, Farkas S, Roth W, Dang H, Hausen A, Gaida MM

10.1002/ctm2.1299

TP22, TPQ1

Spatially Resolved Multi-Omics Single-Cell Analyses Inform Mechanisms of Immune Dysfunction in Pancreatic Cancer

Gastroenterology

Yousuf S, Qiu M, Voith von Voithenberg L, Hulkkonen J, Macinkovic I, Schulz AR, Hartmann D, Mueller F, Mijatovic M, Ibberson D, AlHalabi KT, Hetzer J, Anders S, Brüne B, Mei HE, Imbusch CD, Brors B, Heikenwälder M, Gaida MM, Büchler MW, Weigert A, Hackert T, Roth S

10.1053/j.gastro.2023.05.036

TP22, TPQ1

Using combined single-cell gene expression, TCR sequencing and cell surface protein barcoding to characterize and track CD4+ T cell clones from murine tissues

Front Immunol

Nedwed AS, Helbich SS, Braband KL, Volkmar M, Delacher M, Marini F

10.3389/fimmu.2023.1241283

TP19

Using single-cell chromatin accessibility sequencing to characterize CD4+ T cells from murine tissues

Front Immunol

Braband KL, Nedwed AS, Helbich SS, Simon M, Beumer N, Brors B, Marini F, Delacher M

10.3389/fimmu.2023.1232511

TP19

Colorectal Cancer Organoid-Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses

Cancer Discov

Farin HF, Mosa MH, Ndreshkjana B, Grebbin BM, Ritter B, Menche C, Kennel KB, Ziegler PK, Szabó L, Bollrath J, Rieder D, Michels BE, Kress A, Bozlar M, Darvishi T, Stier S, Kur IM, Bankov K, Kesselring R, Fichtner-Feigl S, Brüne B, Goetze TO, Al-Batran SE, Brandts CH, Bechstein WO, Wild PJ, Weigert A, Müller S, Knapp S, Trajanoski Z, Greten FR

10.1158/2159-8290.CD-23-0050

TP16

NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis

Sci Immunol

Marinović S, Lenartić M, Mladenić K, Šestan M, Kavazović I, Benić A, Krapić M, Rindlisbacher L, Cokarić Brdovčak M, Sparano C, Litscher G, Turk Wensveen T, Mikolašević I, Fučkar Čupić D, Bilić-Zulle L, Steinle A, Waisman A, Hayday A, Tugues S, Becher B, Polić B, Wensveen FM

10.1126/sciimmunol.add1599

TP15

AIM2 promotes TH17 cells differentiation by regulating RORγt transcription activity

iScience

Leite JA, Menezes L, Martins E, Rodrigues TS, Tavares L, Ebering A, Schelmbauer C, Martelossi Cebinelli GC, Zinina V, Golden A, Soshnikova N, Zamboni DS, Cunha FQ, Huber M, Silva JS, Waisman A, Carlos D, Saraiva Câmara NO

10.1016/j.isci.2023.108134

TP15

Cross-presenting Langerhans cells are required for the early reactivation of resident CD8+ memory T cells in the epidermis

Proc Natl Acad Sci U S A

Kamenjarin N, Hodapp K, Melchior F, Harms G, Hartmann AK, Bartneck J, Muth S, Raker VK, Becker C, Brand A, Clausen BE, Radsak MP, Schild H, Probst HC

10.1073/pnas.2219932120

TP13, TP20, TP21

Targeted removal of macrophage-secreted interleukin-1 receptor antagonist protects against lethal Candida albicans sepsis

Immunity

Gander-Bui HTT, Schläfli J, Baumgartner J, Walthert S, Genitsch V, van Geest G, Galván JA, Cardozo C, Graham Martinez C, Grans M, Muth S, Bruggmann R, Probst HC, Gabay C, Freigang S

10.1016/j.immuni.2023.06.023

TP13, TP21

Optimized dithranol-imiquimod-based transcutaneous immunization enables tumor rejection

Front Immunol

Hartmann AK, Bartneck J, Pielenhofer J, Meiser SL, Arnold-Schild D, Klein M, Stassen M, Schild H, Muth S, Probst HC, Langguth P, Grabbe S, Radsak MP

10.3389/fimmu.2023.1238861

TP13, TP21

Tumor-infiltrating CCR2+ inflammatory monocytes counteract specific immunotherapy

Front Immunol

Bartneck J, Hartmann AK, Stein L, Arnold-Schild D, Klein M, Stassen M, Marini F, Pielenhofer J, Meiser SL, Langguth P, Mack M, Muth S, Probst HC, Schild H, Radsak MP

10.3389/fimmu.2023.1267866

TP13, TP21

Short-term predictor for COVID-19 severity from a longitudinal multi-omics study for practical application in intensive care units

Talanta

Kugler S, Hahnefeld L, Kloka JA, Ginzel S, Nürenberg-Goloub E, Zinn S, Vehreschild MJ, Zacharowski K, Lindau S, Ullrich E, Burmeister J, Kohlhammer J, Schwäble J, Gurke R, Dorochow E, Bennett A, Dauth S, Campe J, Knape T, Laux V, Kannt A, Köhm M, Geisslinger G, Resch E, Behrens F

10.1016/j.talanta.2023.125295

TP12

Epigenetic targeting to enhance acute myeloid leukemia-directed immunotherapy

Front Immunol

Rausch J, Ullrich E, Kühn MWM

10.3389/fimmu.2023.1269012

TP12

HowDirty: An R package to evaluate molecular contaminants in LC-MS experiments

Proteomics

Gomez-Zepeda D, Michna T, Ziesmann T, Distler U, Tenzer S

10.1002/pmic.202300134

TP11, TPQ01

IL-17 receptor goes solo in autoimmune inflammation

Immunity

Bittner S, Zipp F

10.1016/j.immuni.2023.08.007

TP09

Implications of immunometabolism for smouldering MS pathology and therapy

Nat Rev Neurol

Bittner S, Pape K, Klotz L, Zipp F

10.1038/s41582-023-00839-6

TP09

The origin of brain malignancies at the blood-brain barrier

Cell Mol Life Sci

McDonald B, Barth K, Schmidt MHH

10.1007/s00018-023-04934-1

TP09

Distinct Lineage of Slow-Cycling Cells Amidst the Prevailing Heterogeneity in Glioblastoma

Cancers (Basel)

Mahajan S, Schmidt MHH

10.3390/cancers15153843

TP09

Intravital Imaging of Thrombosis Models in Mice

Hamostaseologie

Kiouptsi K, Casari M, Mandel J, Gao Z, Deppermann C

10.1055/a-2118-2932

TP08

Regulatory T-cell deficiency leads to features of autoimmune liver disease overlap syndrome in scurfy mice

Front Immunol

Yilmaz K, Haeberle S, Kim YO, Fritzler MJ, Weng SY, Goeppert B, Raker VK, Steinbrink K, Schuppan D, Enk A, Hadaschik EN

10.3389/fimmu.2023.1253649

TP08

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels

mBio

Schüssler M, Schott K, Fuchs NV, Oo A, Zahadi M, Rauch P, Kim B, König R

10.1128/mbio.02252-23

TP04

A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS

J Clin Invest

Johann L, Soldati S, Müller K, Lampe J, Marini F, Klein M, Schramm E, Ries N, Schelmbauer C, Palagi I, Karram K, Assmann JC, Khan MA, Wenzel J, Schmidt MH, Körbelin J, Schlüter D, van Loo G, Bopp T, Engelhardt B, Schwaninger M, Waisman A

10.1172/JCI168314

TP01, TP15, TPQ01

Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27

Proc Natl Acad Sci U S A

Riehl DR, Sharma A, Roewe J, Murke F, Ruppert C, Eming SA, Bopp T, Kleinert H, Radsak MP, Colucci G, Subramaniam S, Reinhardt C, Giebel B, Prinz I, Guenther A, Strand D, Gunzer M, Waisman A, Ward PA, Ruf W, Schäfer K, Bosmann M

10.1073/pnas.2215421120

TP01, TP02, TP15, TP21

Ubiquitination and cell-autonomous immunity

Curr Opin Immunol

Mello-Vieira J, Bopp T, Dikic I

10.1016/j.coi.2023.102368

TP01

Modulation of cellular transcriptome and proteome composition by azidohomoalanine-implications on click chemistry-based secretome analysis

J Mol Med (Berl)

Kirschner F, Arnold-Schild D, Leps C, Łącki MK, Klein M, Chen Y, Ludt A, Marini F, Kücük C, Stein L, Distler U, Sielaff M, Michna T, Riegel K, Rajalingam K, Bopp T, Tenzer S, Schild H

10.1007/s00109-023-02333-4

TP01, TP05, TP11, TP13, TP19

Impact of extended interval dosing of ocrelizumab on immunoglobulin levels in multiple sclerosis

Med

Schuckmann A, Steffen F, Zipp F, Bittner S, Pape K

10.1016/j.medj.2023.05.001

TP09

The Glioma Immune Landscape: A Double-Edged Sword for Treatment Regimens

Cancers (Basel)

Mahajan S, Schmidt MHH, Schumann U

10.3390/cancers15072024

TP09

Menin inhibitor ziftomenib (KO-539) synergizes with drugs targeting chromatin regulation or apoptosis and sensitizes acute myeloid leukemia with MLL rearrangement or NPM1 mutation to venetoclax

Haematologica

Rausch J, Dzama MM, Dolgikh N, Stiller HL, Bohl SR, Lahrmann C, Kunz K, Kessler L, Echchannaoui H, Chen CW, Kindler T, Döhner K, Burrows F, Theobald M, Sasca D, Kühn MWM

10.3324/haematol.2022.282160

TP06, TP12

Crohn's disease proteolytic microbiota enhances inflammation through PAR2 pathway in gnotobiotic mice

Gut Microbes

Santiago A, Hann A, Constante M, Rahmani S, Libertucci J, Jackson K, Rueda G, Rossi L, Rithwick R, Ruf W, Schertzer J, Caminero A, Bercik P, Galipeau HJ, Verdu EF

10.1080/19490976.2023.2205425

TP02

Langerhans cells in the skin and oral mucosa - brothers in arms?

Eur J Immunol

Brand A, Hovav AH, Clausen BE

10.1002/eji.202149499

TP20

Proteomics biomarker discovery for individualized prevention of familial pancreatic cancer using statistical learning

PLoS One

Ha CSR, Müller-Nurasyid M, Petrera A, Hauck SM, Marini F, Bartsch DK, Slater EP, Strauch K

10.1371/journal.pone.0280399

TP19

Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity

Clin Cancer Res

Kennel KB, Bozlar M, De Valk AF, Greten FR

10.1158/1078-0432.CCR-22-1031

TP16

Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression

Gastroenterology

Boonsanay V, Mosa MH, Looso M, Weichenhan D, Ceteci F, Pudelko L, Lechel A, Michel CS, Künne C, Farin HF, Plass C, Greten FR

10.1053/j.gastro.2022.10.036

TP16

Classical DC2 subsets and monocyte-derived DC: Delineating the developmental and functional relationship

Eur J Immunol

Backer RA, Probst HC, Clausen BE

10.1002/eji.202149548

TP13, TP20

Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects

Brain Behav Immun

Daguano Gastaldi V, Bh Wilke J, Weidinger CA, Walter C, Barnkothe N, Teegen B, Luessi F, Stöcker W, Lühder F, Begemann M, Zipp F, Nave KA, Ehrenreich H

10.1016/j.bbi.2022.10.016

TP09

EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory

Cell Mol Life Sci

Barth K, Vasić V, McDonald B, Heinig N, Wagner MC, Schumann U, Röhlecke C, Bicker F, Schumann L, Radyushkin K, Baumgart J, Tenzer S, Zipp F, Meinhardt M, Alitalo K, Tegeder I, Schmidt MHH

10.1007/s00018-023-04685-z

TP09, TPQ01

Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-β1-driven fibrotic remodeling in ischemic heart failure

J Clin Invest

Garlapati V, Molitor M, Michna T, Harms GS, Finger S, Jung R, Lagrange J, Efentakis P, Wild J, Knorr M, Karbach S, Wild S, Vujacic-Mirski K, Münzel T, Daiber A, Brandt M, Gori T, Milting H, Tenzer S, Ruf W, Wenzel P

10.1172/JCI156436

TP02, TPQ01