2022

Cancer-associated fibroblasts in inflammation and anti-tumor immunity

Clin Cancer Res

Kennel KB, Bozlar M, De Valk AF, Greten FR

10.1158/1078-0432.CCR-22-1031

Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Immunity

Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux PA, Rinsch C, Greten FR

Inflammation: the incubator of the tumor microenvironment

Trends Cancer

Denk D, Greten FR

10.1016/j.trecan.2022.07.002

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Nature

Schmitt M, Ceteci F, Gupta J, Pesic M, Böttger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisözü A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR

10.1038/s41586-022-05426-1

TP16

Hepatic interleukin-1 receptor type 1 signalling regulates insulin sensitivity in the early phases of nonalcoholic fatty liver disease

Clin Transl Med

Gehrke N, Hofmann LJ, Straub BK, Rühle F, Waisman A, Galle PR, Schattenberg JM

10.1002/ctm2.1048

TP15

NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition

Mol Metab

Vesting AJ, Jais A, Klemm P, Steuernagel L, Wienand P, Fog-Tonnesen M, Hvid H, Schumacher AL, Kukat C, Nolte H, Georgomanolis T, Altmüller J, Pasparakis M, Schmidt A, Krüger M, Supprian MS, Waisman A, Straub BK, Raschzok N, Bernier M, Birkenfeld AL, Hövelmeyer N, Brüning JC, Wunderlich FT

10.1016/j.molmet.2022.101626

TP15, TP20

Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mic

Cardiovasc Res

Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A

10.1093/cvr/cvab359

TP15

Antigen targeting to dendritic cells: Still a place in future immunotherapy?

Eur J Immunol

Stoitzner P, Romani N, Rademacher C, Probst HC, Mahnke K

10.1002/eji.202149515

TP13

Dithranol as novel co-adjuvant for non-invasive dermal vaccination

NPJ Vaccines

Sohl J, Hartmann AK, Hahlbrock J, Bartneck J, Stassen M, Klein M, Bros M, Grabbe S, Marini F, Woods K, Guezguez B, Mack M, Schild H, Muth S, Melchior F, Probst HC, Langguth P, Radsak MP

10.1038/s41541-022-00530-9

TP13, TP19, TP21

Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia

Leukemia

Koschade SE, Klann K, Shaid S, Vick B, Stratmann JA, Thölken M, Meyer LM, Nguyen TD, Campe J, Moser LM, Hock S, Baker F, Meyer CT, Wempe F, Serve H, Ullrich E, Jeremias I, Münch C, Brandts CH

10.1038/s41375-022-01678-y

Mitochondrial apoptosis: facilitator of NK cell-mediated immunotherapy

Signal Transduct Target Ther

Ullrich E, Vogler M, von Metzler I

10.1038/s41392-022-01126-4

Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects

Brain Behav Immun

Daguano Gastaldi V, Bh Wilke J, Weidinger CA, Walter C, Barnkothe N, Teegen B, Luessi F, Stöcker W, Lühder F, Begemann M, Zipp F, Nave KA, Ehrenreich H

10.1016/j.bbi.2022.10.016

TP09

Multiomic analysis of papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCδ for tumorigenesis

Mol Cancer

Renaud E, Riegel K, Romero R, Suryamohan K, Distler U, Tenzer S, Schad A, Musholt TJ, Rajalingam K

10.1186/s12943-022-01665-y

TP05, TP11, TPQ01

Cellular Immune Dysfunction in Obstructive Sleep Apnea

Front Surg

Ludwig K, Huppertz T, Radsak M, Gouveris H

10.3389/fsurg.2022.890377

TP21

Advocacy of targeting protease-activated receptors in severe coronavirus disease 2019

Br J Pharmacol

Subramaniam S, Ruf W, Bosmann M

10.1111/bph.15587

A cytosolic disulfide bridge-supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A

FEBS J

Voss M, Kleinau G, Gimber N, Janek K, Bredow C, Thery F, Impens F, Schmoranzer J, Scheerer P, Kloetzel PM, Beling A

10.1111/febs.16368

Use of Autoreactive Antibodies in Blood of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasms (IPMN) for Grade Distinction and Detection of Malignancy

Cancers(Basel)

Brindl N, Boekhoff H, Bauer AS, Gaida MM, Dang HT, Kaiser J, Hoheisel JD, Felix K

10.3390/cancers14153562

TP22, TPQ01

Recent advances in targeting protein kinases and pseudokinases in cancer biology

Front Cell Dev Biol

Riegel K, P Vijayarangakannan, P Kechagioglou, K Bogucka, K Rajalingam

10.3389/fcell.2022.942500

TP05

CRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myeloma

OncoImmunology

Bexte T, Alzubi J, Reindl LM, Wendel P, Schubert R, Salzmann-Manrique E, von Metzler I, Cathomen T, Ullrich E

10.1080/2162402X.2022.2081415

Gamma Irradiation Triggers Immune Escape in Glioma-Propagating Cells

Cancers (Basel)

Hoppmann N, Heinig N, Distler U, Kim E, Lennerz V, Krauß Y, Schumann U, Giese A, Tenzer S, Bitar L, Schmidt MHH

10.3390/cancers14112728

TP09, TP11, TPQ01

Stress Granules determine the Development of Obesity-associated Pancreatic Cancer

Cancer Discov

Fonteneau G, Redding A, Hoag-Lee H, Sim ES, Heinrich S, Gaida MM, Grabocka E

10.1158/2159-8290.CD-21-1672

TP22

Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy

Clin Epigenetics

Neuberger EWI, Sontag S, Brahmer A, Philippi KFA, Radsak MP, Wagner W, Simon P

10.1186/s13148-022-01245-3

TP21

Stimulation of a subset of natural killer T cells by CD103 + DC is required for GM-CSF and protection from pneumococcal infection

Cell Rep

Murray MP, Crosby CM, Marcovecchio P, Hartmann N, Chandra S, Zhao M, Khurana A, Zahner SP, Clausen BE, Coleman FT, Mizgerd JP, Mikulski Z, Kronenberg M

10.1016/j.celrep.2021.110209

TP20

NF-κB in control of regulatory T cell development, identity, and function

J Mol Med (Berl)

Hövelmeyer N, Schmidt-Supprian M, Ohnmacht C

10.1007/s00109-022-02215-1

TP20

ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers

Sci Adv

Mooz J, Riegel K, Ps H, Sadanandam A, Marini F, Klein M, Werner U, Roth W, Wilken-Schmitz A, Tegeder I, Rajalingam K

10.1126/sciadv.abk1538

TP05, TP19

Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer

Cancer cell

Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR

10.1016/j.ccell.2022.01.004

Epicutaneous application of Imiquimod to model psoriasis-like skin disease induces water-saving aestivation motifs and vascular inflammation

J Invest Dermatol

Wild J, Ringen J, Bieler T, Knopp T, Lagrange J, Molitor M, Sies K, Kropp A, Keller K, Daiber A, Münzel T, Rauh M, Waisman A, Wenzel P, Titze J, Karbach S

10.1016/j.jid.2022.04.023

TP15

Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure

Cell Death Dis

Gehrke N, Wörns MA, Mann A, Hövelmeyer N, Waisman A, Straub BK, Galle PR, Schattenberg JM

10.1038/s41419-022-04946-y

TP15, TP20

CD4 + T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival

Cell Rep

Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T, Croxford AL, Nikolav A, Hövelmeyer N, von Stebut E, Prinz M, Ubeda C, Maloy KJ, Gagliani N, Flavell RA, Waisman A, Huber S

10.1016/j.celrep.2022.110565

TP15, TP20

Epitope length variants balance protective immune responses and viral escape in HIV-1 infection

Cell Rep

Pymm P, Tenzer S, Wee E, Weimershaus M, Burgevin A, Kollnberger S, Gerstoft J, Josephs TM, Ladell K, McLaren JE, Appay V, Price DA, Fugger L, Bell JI, Schild H, van Endert P, Harkiolaki M, Iversen AKN

10.1016/j.celrep.2022.110449

TP13, TPQ01

Antigen targeting to dendritic cells: Still a place in future immunotherapy?

Eur J Immunol

Stoitzner P, Romani N, Rademacher C, Probst HC, Mahnke K

10.1002/eji.202149515

TP13

Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy

Cell Death Discov

Särchen V, Shanmugalingam S, Kehr S, Reindl LM, Greze V, Wiedemann S, Boedicker C, Jacob M, Bankov K, Becker N, Wehner S, Theilen TM, Gretser S, Gradhand E, Kummerow C, Ullrich E, Vogler M

10.1038/s41420-021-00812-6

Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia

Blood Cancer J

Albinger N, Pfeifer R, Nitsche M, Mertlitz S, Campe J, Stein K, Kreyenberg H, Schubert R, Quadflieg M, Schneider D, Kühn MWM, Penack O, Zhang C, Möker N, Ullrich E

10.1038/s41408-022-00660-2

T Helper Cell Lineage-Defining Transcription Factors: Potent Targets for Specific GVHD Therapy?

Front Immunol

Campe J, Ullrich E

10.3389/fimmu.2021.806529

The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions

Cell Death Dis

Eichler M, Distler U, Nasrullah U, Krishnan A, Kaulich M, Husnjak K, Eberhardt W, Rajalingam K, Tenzer S, Pfeilschifter J, Imre G

10.1038/s41419-022-04829-2

TP05, TP11, TPQ01

Mast Cells Meet Cytomegalovirus: A New Example of Protective Mast Cell Involvement in an Infectious Disease

Cells

Becker S, Reddehase MJ, Lemmermann NA

10.3390/cells11091402

TP11

Host-Adapted Gene Families Involved in Murine Cytomegalovirus Immune Evasion

Viruses

Becker S, Fink A, Podlech J, Reddehase MJ, Lemmermann NA

10.3390/v14010128

TP11

Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation

Int J Mol Sci

Mandel J, Casari M, Stepanyan M, Martyanov A, Deppermann C

10.3390/ijms23073868

TP08

Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease

Hepatology

Karl M, Hasselwander S, Zhou Y, Reifenberg G, Kim YO, Park KS, Ridder DA, Wang X, Seidel E, Hövelmeyer N, Straub BK, Li H, Schuppan D, Xia N

10.1002/hep.32428

TP08, TP20

Fluorescence Correlation Spectroscopy Monitors the Fate of Degradable Nanocarriers in the Blood Stream

Biomacromolecules

Schmitt S, Huppertsberg A, Klefenz A, Kaps L, Mailänder V, Schuppan D, Butt HJ, Nuhn L, Koynov K

10.1021/acs.biomac.1c01407

TP08

Enhanced but variant-dependent serological and cellular immune responses to third-dose BNT162b2 vaccination in patients with multiple myeloma

Cancer Cell

Julius C Enssle, Julia Campe, Sarah Büchel , Alina Moter, Frederic See, Katharina Grießbaum, Michael A Rieger, Sebastian Wolf, Olivier Ballo, Björn Steffen, Hubert Serve, Holger F Rabenau, Marek Widera, Melanie Bremm, Sabine Huenecke, Sandra Ciesek, Ivana von Metzler, Evelyn Ullrich

10.1016/j.ccell.2022.05.003

TP05, TP12

Severe impairment of T-cell responses to BNT162b2 immunization in patients with multiple myeloma

Blood

Julius C Enßle, Julia Campe, Amelie Schwenger, Eliza Wiercinska, Helen Hellstern, Ralf Dürrwald, Michael A Rieger, Sebastian Wolf, Olivier Ballo, Björn Steffen, Hubert Serve, Halvard Bonig, Holger F Rabenau, Marek Widera, Sandra Ciesek, Ivana von Metzler, Evelyn Ullrich

10.1182/blood.2021013429

TP05, TP12

A cytosolic disulfide bridge-supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A

FEBS J

Martin Voss, Gunnar Kleinau, Niclas Gimber, Katharina Janek, Clara Bredow, Fabien Thery, Francis Impens, Jan Schmoranzer, Patrick Scheerer, Peter-Michael Kloetzel, Antje Beling

10.1111/febs.16368

A Conserved Cysteine Residue in Coxsackievirus B3 Protein 3A with Implication for Elevated Virulence

Viruses

Martin Voss, Sandra Pinkert, Meike Kespohl,Niclas Gimber, Karin Klingel, Jan Schmoranzer, Michael Laue, Matthias Gaida, Peter-Michael Kloetzel, Antje Beling

10.3390/v14040769